Overview

  • Product nameAnti-MRP1 antibody [QCRL1]
    See all MRP1 primary antibodies
  • Description
    Mouse monoclonal [QCRL1] to MRP1
  • SpecificityReacts with MRP. This antibody does not cross-react with the human MDR1 and MDR3, or mouse MRP gene products
  • Tested applicationsSuitable for: ICC, IHC-P, IHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse
  • Immunogen

    Membranes prepared from the human small cell lung cancer cell line H68AR.

  • EpitopeReacts with a linear epitope
  • Positive control
    • Cell Lines: Drug-sensitive parental cell lines and their multidrug-resistant derivatives

Properties

Applications

Our Abpromise guarantee covers the use of ab3369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC 1/25 - 1/50.
IHC-P 1/40.
IHC-Fr Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 190 kDa.

Target

  • FunctionMediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
  • Tissue specificityLung, testis and peripheral blood mononuclear cells.
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Cellular localizationCell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ABC 29 antibody
    • ABC29 antibody
    • ABCC 1 antibody
    • ABCC antibody
    • Abcc1 antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 1 antibody
    • ATP binding cassette sub-family C member 1 antibody
    • ATP-binding cassette sub-family C member 1 antibody
    • DKFZp686N04233 antibody
    • DKFZp781G125 antibody
    • GS X antibody
    • GSX antibody
    • Leukotriene C(4) transporter antibody
    • LTC4 transporter antibody
    • MRP 1 antibody
    • MRP antibody
    • MRP1_HUMAN antibody
    • Multidrug resistance associated protein 1 antibody
    • Multidrug resistance protein antibody
    • Multidrug resistance-associated protein 1 antibody
    • Multiple drug resistance associated protein antibody
    • Multiple drug resistance protein 1 antibody
    see all

References for Anti-MRP1 antibody [QCRL1] (ab3369)

This product has been referenced in:
  • Rivers F  et al. Exploring the possible interaction between anti-epilepsy drugs and multidrug efflux pumps; in vitro observations. Eur J Pharmacol 598:1-8 (2008). WB ; Human . Read more (PubMed: 18835265) »

See 1 Publication for this product

Product Wall

Wir haben leider aktuell keinen validierten anti-Housekeeping Protein Antikörper der nur humane Proteine erkennt. Wir wissen, dass der ab3369 Click here (or use the following: http://www.abcam.com/index.html?datasheet=3369) gegen MRP1 nicht mit der Mau...

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Thank you very much for contacting us. Following your request, I have searched our catalog for all antibodies that match the mentioned criteria, i.e. that recognise human targets and that do not react with mouse. Please find attached a list of ...

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Thank you for your enquiry. The concentrations are as follows: ab3369 - ~150 ug/ml ab3370 - ~200 ug/ml Concentrations may vary slightly from lot to lot. I hope this information helps. Please do not hesitate to contact us if you need anything ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"