Anti-MRP2 antibody [M2II-12] (ab24106)

Overview

  • Product nameAnti-MRP2 antibody [M2II-12]
    See all MRP2 primary antibodies
  • Description
    Mouse monoclonal [M2II-12] to MRP2
  • Specificityab24106 reacts with MRP2 (ABCC2) and does not cross react with the human MDR1, MRP1, MRP3 and MRP5 gene products.
  • Tested applicationsSuitable for: ICC, Flow Cyt, WB, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Fusion protein:

    K TFLRHTGPEE EATVHDGSEE EDDDYGLISS VEEIPEDAAS ITMRRENSFR RTLSRSSRSN GRHLKSLRNS LKTRNVNSLK EDEELVKGQK

    , corresponding to Internal sequence amino acids 860-950 of Human MRP2

Properties

Applications

Our Abpromise guarantee covers the use of ab24106 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC
Flow Cyt
WB
IHC-Fr
  • Application notesFlow Cyt: Use at an assay dependent dilution.
    ICC: Use at 1/20-1/50 dilution on acetone fixed cytospin preparations.
    IHC-Fr: Use at 1/20 dilution. Acetone fixed.
    WB: 1/20-1/50. Detects a band of approximately 190-200 kDa.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
    • Tissue specificityFound on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
    • Involvement in diseaseDefects in ABCC2 are the cause of Dubin-Johnson syndrome (DJS) [MIM:237500]. DJS is an autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function.
    • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
      Contains 2 ABC transmembrane type-1 domains.
      Contains 2 ABC transporter domains.
    • Cellular localizationMembrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • ABC30 antibody
      • abcC2 antibody
      • ATP binding cassette sub family C (CFTR/MRP) member 2 antibody
      • ATP binding cassette subfamily C member 2 antibody
      • ATP-binding cassette sub-family C member 2 antibody
      • Canalicular multidrug resistance protein antibody
      • Canalicular multispecific organic anion transporter 1 antibody
      • CMOAT antibody
      • CMOAT1 antibody
      • cMRP antibody
      • DJS antibody
      • KIAA1010 antibody
      • MRP 2 antibody
      • MRP2_HUMAN antibody
      • Multidrug resistance associated protein 2 antibody
      • Multidrug resistance-associated protein 2 antibody
      see all

    References for Anti-MRP2 antibody [M2II-12] (ab24106)

    ab24106 has not yet been referenced specifically in any publications.

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