Overview

  • Product name
  • Description
    Mouse polyclonal to MRP6
  • Host species
    Mouse
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-99 of Human MRP6 (NP_001072996.1).

  • Positive control
    • MRP6 transfected 293T cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab167564 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 11 kDa.

Target

  • Function
    May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
  • Tissue specificity
    Expressed in kidney and liver. Very low expression in other tissues.
  • Involvement in disease
    Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE).
  • Sequence similarities
    Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Cellular localization
    Membrane. Localized to the basolateral membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ABC34 antibody
    • Abcc6 antibody
    • Anthracycline resistance-associated protein antibody
    • ARA antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 6 antibody
    • ATP binding cassette sub family C member 6 antibody
    • ATP-binding cassette sub-family C member 6 antibody
    • EST349056 antibody
    • GACI2 antibody
    • MLP1 antibody
    • MOAT E antibody
    • MOAT-E antibody
    • MOATE antibody
    • MRP 6 antibody
    • MRP6 antibody
    • MRP6_HUMAN antibody
    • Multi-specific organic anion transporter E antibody
    • Multidrug resistance associated protein 6 antibody
    • Multidrug resistance-associated protein 6 antibody
    • Multidrug resistance-associated protein 6; URG7 protein antibody
    • multispecific organic anion transporter E antibody
    • PXE antibody
    • PXE1 antibody
    • URG7 antibody
    • URG7 protein antibody
    see all

Images

  • All lanes : Anti-MRP6 antibody (ab167564) at 1 µg/ml

    Lane 1 : MRP6 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell line

    Lysates/proteins at 15 µl per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size: 11 kDa

References

ab167564 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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