Overview

  • Product nameAnti-MRP6 antibody
    See all MRP6 primary antibodies
  • Description
    Mouse monoclonal to MRP6
  • Tested applicationsSuitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Recombinant Fragment
    Predicted to work with: Human
  • Immunogen

    Recombinant fragment, corresponding to amino acids 831-931 of Human MRP6 with tag (NP_001162).

  • Positive control
    • Recombinant fragment of human MRP6.

Properties

Applications

Our Abpromise guarantee covers the use of ab54826 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent dilution. Detection limit for recombinant tagged ABCC6 is approximately 0.03ng/ml if used as a capture antibody.
WB 1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 164 kDa).

Target

  • FunctionMay participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
  • Tissue specificityExpressed in kidney and liver. Very low expression in other tissues.
  • Involvement in diseaseDefects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE) [MIM:264800]. PXE is a disorder characterized by calcification of elastic fibers in skin, arteries and retina that results in dermal lesions with associated laxity and loss of elasticity, arterial insufficiency and retinal hemorrhages leading to macular degeneration. PXE is caused in the overwhelming majority of cases by homozygous or compound heterozygous mutations in the ABCC6 gene (autosomal recessive PXE). Individuals carrying heterozygous mutations express limited manifestations of the pseudoxanthoma elasticum phenotype (autosomal dominant PXE).
  • Sequence similaritiesBelongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.
    Contains 2 ABC transmembrane type-1 domains.
    Contains 2 ABC transporter domains.
  • Cellular localizationMembrane. Localized to the basolateral membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • ABC34 antibody
    • Abcc6 antibody
    • Anthracycline resistance-associated protein antibody
    • ARA antibody
    • ATP binding cassette sub family C (CFTR/MRP) member 6 antibody
    • ATP binding cassette sub family C member 6 antibody
    • ATP-binding cassette sub-family C member 6 antibody
    • EST349056 antibody
    • MLP1 antibody
    • MOAT E antibody
    • MOAT-E antibody
    • MOATE antibody
    • MRP 6 antibody
    • MRP6 antibody
    • MRP6_HUMAN antibody
    • Multi-specific organic anion transporter E antibody
    • Multidrug resistance associated protein 6 antibody
    • Multidrug resistance-associated protein 6 antibody
    • multispecific organic anion transporter E antibody
    • PXE antibody
    • PXE1 antibody
    • URG7 antibody
    • URG7 protein antibody
    see all

Anti-MRP6 antibody images

  • Anti-MRP6 antibody (ab54826) at 1/500 dilution + Recombinant fragment of human MRP6 at 0.2 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/5000 dilution

    Predicted band size : 164 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)

References for Anti-MRP6 antibody (ab54826)

ab54826 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"