• Product name
    Anti-MRP8 + MRP14 antibody (Biotin)
    See all MRP8 + MRP14 primary antibodies
  • Description
    Chicken polyclonal to MRP8 + MRP14 (Biotin)
  • Conjugation
  • Specificity
    Does not discriminate between the individual subunits MRP8 or MRP14.
  • Tested applications
    Suitable for: ELISA, IHC-Fr, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant MRP8/14 heterocomplex (Human). The antigen is produced by the Ca2+ dependent heterocomplex formation of MRP8 (S100A8 or Calgranulin A) and MRP14 (S100A9 or Calgranulin B), two calcium binding proteins of the S 100 protein family.

  • Positive control
    • Human tonsil.
  • General notes
    Peripheral blood monocytes carry the antigen extra and intracellularly, neutrophils only intracellularly. The antigen is present on macrophages in the red pulp of the spleen and in the liver. It is also strongly expressed on macrophages in acute inflamed tissues (peridontitis, contact excema, urticaria, erythrodermia).

    In immune histochemistry, this antibody detects early inflammatory macrophages and can thus be used for the classification of acute stage inflammation in tissue sections and in smears.


  • Form
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: Kathon
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • Purity
    IgY fraction
  • Purification notes
    Purified from egg yolk by repeated precipitation.
  • Primary antibody notes
    In immune histochemistry, this antibody detects early inflammatory macrophages and can thus be used for the classification of acute stage inflammation in tissue sections and in smears.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab51863 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
IHC-Fr Use a concentration of 1 µg/ml.


IHC-P Use a concentration of 4 µg/ml.

1/250. Proteinase K pretreatment for antigen retrieval is recommended.


  • Relevance
    MRP8 and MRP14 are members of the S100 family of proteins containing 2 EF hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21.
  • Cellular localization
    Cytoplasmic and Nuclear
  • Database links
  • Alternative names
    • CAGA antibody
    • CAGB antibody
    • Calgranulin A antibody
    • Calgranulin B antibody
    • Calprotectin L1L subunit antibody
    • CFAG antibody
    • CP10 antibody
    • Cystic fibrosis antigen antibody
    • Leukocyte L1 complex light chain antibody
    • Macrophage L1 protein Calprotectin antibody
    • Migration inhibitory factor related protein 14 antibody
    • Migration inhibitory factor related protein 8 antibody
    • MRP-14 antibody
    • MRP-8 antibody
    • P14 antibody
    • P8 antibody
    • S100 calcium binding protein A8 antibody
    • S100 calcium binding protein A9 antibody
    • S100A8 antibody
    • S100A9 antibody
    • Urinary stone protein band A antibody
    see all

Anti-MRP8 + MRP14 antibody (Biotin) images

  • ab51863 at 4µg/ml staining human spleen; paraffin embedded.

References for Anti-MRP8 + MRP14 antibody (Biotin) (ab51863)

This product has been referenced in:
  • Lood C  et al. Protein synthesis of the pro-inflammatory S100A8/A9 complex in plasmacytoid dendritic cells and cell surface S100A8/A9 on leukocyte subpopulations in systemic lupus erythematosus. Arthritis Res Ther 13:R60 (2011). ELISA . Read more (PubMed: 21492422) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab51863.
Please use the links above to contact us or submit feedback about this product.


Sign up