Overview

  • Product name
    Anti-MRPL41 antibody
    See all MRPL41 primary antibodies
  • Description
    Rabbit polyclonal to MRPL41
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR, corresponding to amino acids 71-137 of Human MRPL41.

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control
    • Human rectum tissue; RT-4 and U-251 MG cell lysates; U-251MG cells

Properties

Applications

Our Abpromise guarantee covers the use of ab121821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100

Target

  • Function
    Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
  • Tissue specificity
    Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
  • Sequence similarities
    Belongs to the ribosomal protein L41 family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
    • Alternative names
      • 39S ribosomal protein L27 homolog antibody
      • 39S ribosomal protein L41 antibody
      • 39S ribosomal protein L41 mitochondrial antibody
      • Bcl-2-interacting mitochondrial ribosomal protein L41 antibody
      • BMRP antibody
      • Cell proliferation-inducing gene 3 protein antibody
      • L41mt antibody
      • mitochondrial antibody
      • Mitochondrial ribosomal protein L41 antibody
      • MRP L27 antibody
      • MRP-L27 homolog antibody
      • MRP-L41 antibody
      • MRPL27 antibody
      • mRpL41 antibody
      • PIG3 antibody
      • Proliferation inducing gene 3 antibody
      • RM41_HUMAN antibody
      • RPML27 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL41 antibody (ab121821)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MRPL41 antibody (ab121821)
      ab121821, at 1/300 dilution, staining MRPL41 in paraffin-embedded Human rectum tissue by Immunohistochemistry.
    • Western blot - Anti-MRPL41 antibody (ab121821)
      Western blot - Anti-MRPL41 antibody (ab121821)
      All lanes : Anti-MRPL41 antibody (ab121821) at 1/250 dilution

      Lane 1 : RT-4 cell lysate
      Lane 2 : U-251 MG cell lysate
      Lane 3 : Human Plasma lysate
      Lane 4 : Human Liver lysate
      Lane 5 : Human Tonsil lysate
    • Immunocytochemistry/ Immunofluorescence - Anti-MRPL41 antibody (ab121821)
      Immunocytochemistry/ Immunofluorescence - Anti-MRPL41 antibody (ab121821)
      ab121821, at 4µg/ml, staining MRPL41 in U-251MG cells by Immunofluorescence. Antibody staining is shown in green.

    References

    ab121821 has not yet been referenced specifically in any publications.

    Publishing research using ab121821? Please let us know so that we can cite the reference in this datasheet.

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