Overview

  • Product name
  • Description
    Rabbit polyclonal to MRPL41
  • Tested applications
    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: KPYVSYLAPE SEETPLTAAQ LFSEAVAPAI EKDFKDGTFD PDNLEKYGFE PTQEGKLFQL YPRNFLR, corresponding to amino acids 71-137 of Human MRPL41.

  • Positive control
    • Human rectum tissue; RT-4 and U-251 MG cell lysates; U-251MG cells

Properties

Applications

Our Abpromise guarantee covers the use of ab121821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/250 - 1/500.
ICC/IF Use a concentration of 1 - 4 µg/ml. Fixation/Permeabilization: PFA/Triton X-100

Target

  • Function
    Component of the mitochondrial ribosome large subunit. Also involved in apoptosis and cell cycle. Enhances p53/TP53 stability, thereby contributing to p53/TP53-induced apoptosis in response to growth-inhibitory condition. Enhances p53/TP53 translocation to the mitochondria. Has the ability to arrest the cell cycle at the G1 phase, possibly by stabilizing the CDKN1A and CDKN1B (p27Kip1) proteins.
  • Tissue specificity
    Present in kidney, liver, thymus and testis, and at lower level in brain and spleen (at protein level).
  • Sequence similarities
    Belongs to the ribosomal protein L41 family.
  • Cellular localization
    Mitochondrion.
  • Information by UniProt
  • Database links
  • Alternative names
    • 39S ribosomal protein L27 homolog antibody
    • 39S ribosomal protein L41 antibody
    • 39S ribosomal protein L41 mitochondrial antibody
    • Bcl-2-interacting mitochondrial ribosomal protein L41 antibody
    • BMRP antibody
    • Cell proliferation-inducing gene 3 protein antibody
    • L41mt antibody
    • mitochondrial antibody
    • Mitochondrial ribosomal protein L41 antibody
    • MRP L27 antibody
    • MRP-L27 homolog antibody
    • MRP-L41 antibody
    • MRPL27 antibody
    • mRpL41 antibody
    • PIG3 antibody
    • Proliferation inducing gene 3 antibody
    • RM41_HUMAN antibody
    • RPML27 antibody
    see all

Images

  • ab121821, at 1/300 dilution, staining MRPL41 in paraffin-embedded Human rectum tissue by Immunohistochemistry.
  • All lanes : Anti-MRPL41 antibody (ab121821) at 1/250 dilution

    Lane 1 : RT-4 cell lysate
    Lane 2 : U-251 MG cell lysate
    Lane 3 : Human Plasma lysate
    Lane 4 : Human Liver lysate
    Lane 5 : Human Tonsil lysate
  • ab121821, at 4µg/ml, staining MRPL41 in U-251MG cells by Immunofluorescence. Antibody staining is shown in green.

References

ab121821 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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