Overview

  • Product nameMRS 2211
  • Description
    Selective, competitive P2Y13 antagonist
  • Biological descriptionSelective, competitive P2Y13 antagonist (pA2 = 6.3). Displays >20-fold selectivity over P2Y1 and P2Y12 (IC50 > 10 μM for inhibition of human P2Y1 and human P2Y12 receptor-mediated phospholipase C responses).
  • Purity> 95%

Properties

  • Chemical name2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde sodium salt
  • Molecular weight496.64
  • Chemical structureChemical Structure
  • Molecular formulaC14H9ClN4Na3O8P
  • Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 70 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES[O-][N+](=O)c2cc(/N=N/c1nc(C)c(O[Na])c(c1COP(=O)(O[Na])O[Na])C=O)c(Cl)cc2
  • Source

    Synthetic

  • Research areas

    References for MRS 2211 (ab120445)

    This product has been referenced in:
    • Jacobson KA  et al. Development of selective agonists and antagonists of P2Y receptors. Purinergic Signal 5:75-89 (2009). Read more (PubMed: 18600475) »
    • Carrasquero LM  et al. P2X7 and P2Y13 purinergic receptors mediate intracellular calcium responses to BzATP in rat cerebellar astrocytes. J Neurochem 110:879-89 (2009). Read more (PubMed: 19457067) »
    • von Kügelgen I Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110:415-32 (2006). Read more (PubMed: 16257449) »
    • Kim YC  et al. Synthesis of pyridoxal phosphate derivatives with antagonist activity at the P2Y13 receptor. Biochem Pharmacol 70:266-74 (2005). Read more (PubMed: 15913566) »

    See 1 Publication for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"