The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use 2-10 µg for µg of chromatin.
Application notesIs unsuitable for WB.
FunctionRNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
Tissue specificityUbiquitous; detected at low levels.
Involvement in diseaseNote=Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
Sequence similaritiesBelongs to the Musashi family. Contains 2 RRM (RNA recognition motif) domains.
Cellular localizationCytoplasm. Associated with polysomes.
Detection of MSI2 by Western Blot of Immunprecipitate.
An antibody to MSI2 at 1µg/ml staining MSI2 in HeLa whole cell lysate immunoprecipitated using ab114083 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with exposure time of 30 seconds.
References for Anti-MSI2 antibody (ab114083)
has not yet been referenced specifically in any publications.
Publishing research using ab114083? Please let us know so that we can cite the reference in this datasheet.
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