Overview

  • Product nameAnti-mSin3A antibody
    See all mSin3A primary antibodies
  • Description
    Rabbit polyclonal to mSin3A
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Horse, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region within residues 1 - 50 of Human mSin3A (NP_056292.1)

  • Positive control
    • Human ovarian tumor; Mouse squamous cell carcinoma.

Properties

Applications

Our Abpromise guarantee covers the use of ab84380 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.
    Note: expected to work on frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActs as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3A to DNA. Acts as a corepressor for REST.
    • Sequence similaritiesContains 3 PAH (paired amphipathic helix) domains.
    • Post-translational
      modifications
      SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.
    • Cellular localizationNucleus. Nucleus > nucleolus. Recruited to the nucleolus by SAP30L.
    • Information by UniProt
    • Database links
    • Alternative names
      • AW553200 antibody
      • DKFZP434K2235 antibody
      • FLJ90319 antibody
      • Histone deacetylase complex subunit Sin 3a antibody
      • Histone deacetylase complex subunit Sin3a antibody
      • KIAA0700 antibody
      • Kiaa4126 antibody
      • mKIAA4126 antibody
      • Paired amphipathic helix protein Sin 3a antibody
      • Paired amphipathic helix protein Sin3a antibody
      • Sin 3a antibody
      • SIN3 homolog A antibody
      • SIN3 homolog A transcription regulator (yeast) antibody
      • SIN3 homolog A transcription regulator antibody
      • SIN3 transcription regulator homolog A antibody
      • Sin3a antibody
      • SIN3A protein antibody
      • SIN3A_HUMAN antibody
      • Transcriptional co repressor Sin 3A antibody
      • Transcriptional co repressor Sin3A antibody
      • Transcriptional corepressor Sin3a antibody
      • Transcriptional regulator SIN3A antibody
      see all

    Anti-mSin3A antibody images

    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Mouse squamous cell carcinoma tissue using 1/250 ab84380. Detection: DAB staining.
    • Immunohistochemistry analysis of formalin-fixed, paraffin-embedded Human ovarian tumor tissue using 1/250 ab84380. Detection: DAB staining.

    References for Anti-mSin3A antibody (ab84380)

    ab84380 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"