• Product name
  • Description
    Rabbit polyclonal to MSK1
  • Host species
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human MSK1 aa 551-600 (internal sequence).
    Database link: O75582

  • Positive control
    • Human brain cortex neurons tissue, Human heart tissue, 293 cells, Huvec cells



Our Abpromise guarantee covers the use of ab155405 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 90 kDa.

Please Note: ab155405 has only been tested in lysates from cells which have undergone stress.

IHC-P Use a concentration of 5 µg/ml.
ICC/IF 1/100 - 1/500.


  • Function
    Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and epidemal growth-factor (EGF), which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14).
  • Tissue specificity
    Widely expressed with high levels in heart, brain and placenta. Less abundant in lung, kidney and liver.
  • Sequence similarities
    Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.
    Contains 1 AGC-kinase C-terminal domain.
    Contains 2 protein kinase domains.
  • Post-translational
    Ser-376 and Thr-581 phosphorylation is required for kinase activity. Ser-376 and Ser-212 are autophosphorylated by the C-terminal kinase domain, and their phosphorylation is essential for the catalytic activity of the N-terminal kinase domain.
  • Cellular localization
    Nucleus. Cytoplasm. Predominantly nuclear. Partially cytoplasmic.
  • Information by UniProt
  • Database links
  • Alternative names
    • 90 kDa ribosomal protein S6 kinase 5 antibody
    • EC antibody
    • KS6A5_HUMAN antibody
    • MGC1911 antibody
    • Mitogen and stress activated protein kinase 1 antibody
    • MSPK1 antibody
    • Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody
    • Nuclear mitogen- and stress-activated protein kinase 1 antibody
    • Ribosomal protein S6 kinase 90kD polypeptide 5 antibody
    • Ribosomal protein S6 kinase 90kDa antibody
    • Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody
    • Ribosomal Protein S6 Kinase Alpha 5 antibody
    • Ribosomal protein S6 kinase alpha-5 antibody
    • RLPK antibody
    • RPS6KA5 antibody
    • RSK Like Protein Kinase antibody
    • RSK-like protein kinase antibody
    • RSKL antibody
    • S6K alpha 5 antibody
    • S6K-alpha-5 antibody
    see all


  • All lanes : Anti-MSK1 antibody (ab155405) at 1/500 dilution

    Lane 1 : 293 cells treated with UV for 15 minutes
    Lane 2 : 293 cells treated with UV for 15 minutes with synthesised peptide

    Predicted band size: 90 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain, cortex neurons tissue labeling MSK1 using ab155405 at 5 µg/ml.
  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling MSK1 using ab155405 at 5 µg/ml.
  • Immunofluorescence analysis of Huvec cells, labeling MSK1 using ab155405 at a 1/100 dilution. The image on the right is treated with the synthesized peptide.


ab155405 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab155405.
Please use the links above to contact us or submit feedback about this product.


Sign up