Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.03 - 0.1 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 81 kDa).

Target

  • Function
    May be involved in the regulation of gene expression by covalent modification of histone proteins. Isoform Long is a corepressor of estrogen receptor (ER). Isoform Short binds to ER and sequesters it in the cytoplasm and enhances non-genomic responses of ER.
  • Tissue specificity
    Widely expressed. High expression in brain, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual.
  • Sequence similarities
    Contains 1 BAH domain.
    Contains 1 ELM2 domain.
    Contains 1 GATA-type zinc finger.
    Contains 1 SANT domain.
  • Developmental stage
    Highly expressed in metastatic cells.
  • Domain
    Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif).
  • Cellular localization
    Cytoplasm and Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • Metastasis associated 1 antibody
    • Metastasis associated gene 1 antibody
    • Metastasis associated gene 1 protein antibody
    • Metastasis associated protein antibody
    • Metastasis associated protein MTA 1 antibody
    • Metastasis associated protein MTA1 antibody
    • Metastasis-associated protein MTA1 antibody
    • MTA 1 antibody
    • MTA1 antibody
    • MTA1_HUMAN antibody
    see all

Images



  • Predicted band size : 81 kDa
    ab751 at a concentration of 0.5µg/ml staining approximately 80kDa MTA1 in placental lysate (RIPA buffer, 35µg total protein per lane) by Western blot (ECL).    ab751 at a concentration of 0.5µg/ml staining approximately 80kDa MTA1 in placental lysate (RIPA buffer, 35µg total protein per lane) by Western blot (ECL).

References

This product has been referenced in:
  • Porter LF  et al. A role for repressive complexes and H3K9 di-methylation in PRDM5-associated brittle cornea syndrome. Hum Mol Genet 24:6565-79 (2015). IP ; Human . Read more (PubMed: 26395458) »
  • Weng W  et al. Metastasis-associated protein 1 promotes tumor invasion by downregulation of E-cadherin. Int J Oncol 44:812-8 (2014). Human . Read more (PubMed: 24424621) »

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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