Overview

  • Product nameAnti-MTA2 antibody
    See all MTA2 primary antibodies
  • Description
    Rabbit polyclonal to MTA2
  • Tested applicationsSuitable for: WB, IP, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Horse, Cow, Chimpanzee, Rhesus monkey, Orangutan
  • Immunogen

    Synthetic peptide:

    PAPSHPASTNEPIVLED

    , corresponding to amino acids 652-668 of Human MTA2

  • Positive control
    • HeLa Cell Lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab66051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 1 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 75 kDa).
IP Use a concentration of 2 - 5 µg/ml.
ELISA Use a concentration of 0.01 - 0.1 µg/ml.

Target

  • RelevanceThe p53 tumor suppressor gene integrates numerous signals that control cell life and death. There are several proteins that are involved in the p53 pathway, including Chk2, p53R2, p53AIP1, Noxa, PIDD, and MTA2. The transcriptional activity of p53 is modulated by protein stability and acetylation. MTA2, also termed MTA1L1, was found to be a subunit of nucleosome remodeling and deacetylating (NuRD) complex. MTA2 modulates the enzymatic activity of the histone deacetylase complex and its expression reduces the levels of acetylated p53. Deacetylation of p53 by MTA2 represses p53 dependent transcriptional activation and modulates p53 mediated cell growth arrest and apoptosis. MTA2 is ubiquitously expressed in human tissues.
  • Cellular localizationNuclear
  • Database links
  • Alternative names
    • DKFZp686F2281 antibody
    • Mata1l1 antibody
    • Metastasis associated 1 family member 2 antibody
    • Metastasis associated 1 like 1 antibody
    • Metastasis associated gene 1 like 1 antibody
    • Metastasis associated gene family member 2 antibody
    • Metastasis associated protein 2 antibody
    • Metastasis associated protein MTA 2 antibody
    • Metastasis associated protein MTA2 antibody
    • Mmta2 antibody
    • MTA1 L1 protein antibody
    • MTA1L1 antibody
    • p53 target protein in deacetylase complex antibody
    • PID antibody
    see all

Anti-MTA2 antibody images

  • All lanes : Anti-MTA2 antibody (ab66051) at 1 µg/ml

    Lane 1 : HeLa whole cell lysate
    Lane 2 : HeLa whole cell lysate with immunising peptide


    Predicted band size : 75 kDa
    Observed band size : 75 kDa
    Additional bands at : 65 kDa. We are unsure as to the identity of these extra bands.

References for Anti-MTA2 antibody (ab66051)

ab66051 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"