Overview

  • Product name
    Anti-MTBP antibody [PHL-1]
    See all MTBP primary antibodies
  • Description
    Mouse monoclonal [PHL-1] to MTBP
  • Specificity
    ab34704 recognises MTBP protein.
  • Tested applications
    Suitable for: ELISA, WBmore details
  • Species reactivity
    Reacts with: Human, Chimpanzee
    Does not react with: Mouse, Chicken
  • Immunogen

    Recombinant amino-terminal HIS6X-tagged polypeptide corresponding to amino acid residues

    667-812

    of human MTBP protein.

  • Positive control
    • 293 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab34704 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/2000 - 1/20000.
WB 1/200 - 1/2000. Predicted molecular weight: 102 kDa.

Target

  • Function
    Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation.
  • Sequence similarities
    Belongs to the MTBP family.
  • Information by UniProt
  • Database links
  • Alternative names
    • hMTBP antibody
    • MDM 2 binding protein antibody
    • MDM 2 BP antibody
    • MDM2 (mouse double minute 2) binding protein 104kD antibody
    • MDM2 (mouse double minute 2) binding protein antibody
    • MDM2 binding protein antibody
    • MDM2 BP antibody
    • Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa antibody
    • Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein antibody
    • Mdm2 transformed 3T3 cell double minute 2 p53 binding protein binding protein antibody
    • Mdm2-binding protein antibody
    • MDM2BP antibody
    • Mouse double minute 2 homolog binding protein antibody
    • MTBP antibody
    • MTBP_HUMAN antibody
    see all

Images

  • All lanes : Anti-MTBP antibody [PHL-1] (ab34704) at 1/500 dilution

    Lane 1 : 293 cell lysate with transfection with a full length human expression MTBP construct.
    Lane 2 : 293 cell lysate without transfection with a full length human expression MTBP construct.

    Developed using the ECL technique

    Predicted band size : 102 kDa
    Observed band size : 110 kDa (why is the actual band size different from the predicted?)

References

This product has been referenced in:

See all 3 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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