Overview

  • Product nameAnti-MTCO2 antibody [4B12A5]
    See all MTCO2 primary antibodies
  • Description
    Mouse monoclonal [4B12A5] to MTCO2
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Saccharomyces cerevisiae
  • Immunogen

    Saccharomyces cerevisiae Cytochrome C oxidase subunit II

  • Positive control
    • Mitochondria from yeast membrane extract
  • General notes

    Product was previously marketed under the MitoSciences sub-brand.

Properties

Applications

Our Abpromise guarantee covers the use of ab110271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 µg/ml. Predicted molecular weight: 26 kDa.

Target

  • FunctionCytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
  • Involvement in diseaseDefects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • Sequence similaritiesBelongs to the cytochrome c oxidase subunit 2 family.
  • Cellular localizationMitochondrion inner membrane.
  • Information by UniProt
  • Database links
    • Alternative names
      • COII antibody
      • COX2 antibody
      • COX2_HUMAN antibody
      • COXII antibody
      • Cytochrome c oxidase II antibody
      • Cytochrome c oxidase polypeptide II antibody
      • Cytochrome c oxidase subunit 2 antibody
      • MT CO2 antibody
      • MT-CO2 antibody
      • MTCO2 antibody
      see all

    Anti-MTCO2 antibody [4B12A5] images

    • Anti-MTCO2 antibody [4B12A5] (ab110271) at 2 µg/ml + Mitochondria from yeast membrane extract at 10 µg

      Predicted band size : 26 kDa

    References for Anti-MTCO2 antibody [4B12A5] (ab110271)

    This product has been referenced in:
    • Atkinson A  et al. Mzm1 influences a labile pool of mitochondrial zinc important for respiratory function. J Biol Chem 285:19450-9 (2010). Read more (PubMed: 20404342) »
    • Di Bella D  et al. Mutations in the mitochondrial protease gene AFG3L2 cause dominant hereditary ataxia SCA28. Nat Genet 42:313-21 (2010). Read more (PubMed: 20208537) »

    See all 26 Publications for this product

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    The immunogens are as follows;

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