Overview

  • Product name
    Anti-MTCO2 antibody [4B12A5]
    See all MTCO2 primary antibodies
  • Description
    Mouse monoclonal [4B12A5] to MTCO2
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Saccharomyces cerevisiae
  • Immunogen

    Saccharomyces cerevisiae Cytochrome C oxidase subunit II

  • Positive control
    • Mitochondria from yeast membrane extract
  • General notes

    This antibody clone is manufactured by Abcam.

    Product was previously marketed under the MitoSciences sub-brand.

Properties

Applications

Our Abpromise guarantee covers the use of ab110271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 2 µg/ml. Predicted molecular weight: 26 kDa.

Target

  • Function
    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
  • Involvement in disease
    Defects in MT-CO2 are a cause of mitochondrial complex IV deficiency (MT-C4D) [MIM:220110]; also known as cytochrome c oxidase deficiency. A disorder of the mitochondrial respiratory chain with heterogeneous clinical manifestations, ranging from isolated myopathy to severe multisystem disease affecting several tissues and organs. Features include hypertrophic cardiomyopathy, hepatomegaly and liver dysfunction, hypotonia, muscle weakness, excercise intolerance, developmental delay, delayed motor development and mental retardation. A subset of patients manifest Leigh syndrome.
  • Sequence similarities
    Belongs to the cytochrome c oxidase subunit 2 family.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
    • Alternative names
      • COII antibody
      • COX2 antibody
      • COX2_HUMAN antibody
      • COXII antibody
      • Cytochrome c oxidase II antibody
      • Cytochrome c oxidase polypeptide II antibody
      • Cytochrome c oxidase subunit 2 antibody
      • MT CO2 antibody
      • MT-CO2 antibody
      • MTCO2 antibody
      see all

    Anti-MTCO2 antibody [4B12A5] images

    • Anti-MTCO2 antibody [4B12A5] (ab110271) at 2 µg/ml + Mitochondria from yeast membrane extract at 10 µg

      Predicted band size : 26 kDa

    References for Anti-MTCO2 antibody [4B12A5] (ab110271)

    This product has been referenced in:
    • de Taffin de Tilques M  et al. Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome. Dis Model Mech 10:439-450 (2017). WB . Read more (PubMed: 28188263) »
    • Kaniak-Golik A  et al. Activation of Dun1 in response to nuclear DNA instability accounts for the increase in mitochondrial point mutations in Rad27/FEN1 deficient S. cerevisiae. PLoS One 12:e0180153 (2017). WB ; Saccharomyces cerevisiae . Read more (PubMed: 28678842) »

    See all 21 Publications for this product

    Product Wall

    Thank you for contacting us.

    The immunogens are as follows;

    ab79393; A synthetic peptide corresponding to residues in human Cytochrome C oxidase subunit II
    ab109739; A synthetic peptide corresponding to residues in Human Cytochro...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

    Sign up