Overview

  • Product nameMTEP hydrochloride
  • Description
    Potent, selective mGlu5 antagonist
  • Biological descriptionBrain penetrant, potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM in Ca2+-flux assay; Ki = 16 nM). In vivo anxiolytic, devoid of side effects seen with MPEP and benzodiazepines. Also available in Kit: mGlu antagonists (ab120322).

    Also available in simple stock solutions (ab144485) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity> 99%

Properties

    References for MTEP hydrochloride (ab120035)

    This product has been referenced in:
    • Varty GB  et al. The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. Psychopharmacology (Berl) 179:207-17 (2005). Read more (PubMed: 15682298) »
    • Cosford ND  et al. 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. J Med Chem 46:204-6 (2003). Read more (PubMed: 12519057) »
    • Anderson JJ  et al. In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). Eur J Pharmacol 473:35-40 (2003). Read more (PubMed: 12877935) »

    See all 14 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"