Overview

  • Product nameAnti-MTGR1 antibody [KT42]
    See all MTGR1 primary antibodies
  • Description
    Rat monoclonal [KT42] to MTGR1
  • Tested applicationsSuitable for: IP, WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide (Mouse)

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Store at 4°C (stable for up to 12 months). Store at -20°C or -80°C.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone numberKT42
  • IsotypeIgG2c
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab53363 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP Use at an assay dependent dilution.
WB 1/250 - 1/2500. Predicted molecular weight: 67 kDa.

Target

  • FunctionMay function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.
  • Tissue specificityUbiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.
  • Sequence similaritiesBelongs to the CBFA2T family.
    Contains 1 MYND-type zinc finger.
    Contains 1 TAFH (NHR1) domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • AML1 MTG8 antibody
    • cbfa2t2 antibody
    • Core binding factor runt domain alpha subunit 2 translocated to 2 antibody
    • core-binding factor, runt domain, alpha subunit 2 antibody
    • DKFZp313F2116 antibody
    • EHT antibody
    • ETO homolog on chromosome 20 antibody
    • ETO homologous on chromosome 20 antibody
    • MTG 8 like protein antibody
    • MTG 8 related protein 1 antibody
    • MTG8 like protein antibody
    • MTG8 related protein 1 antibody
    • MTG8-like protein antibody
    • MTG8-related protein 1 antibody
    • MTG8R_HUMAN antibody
    • MTGR 1 antibody
    • Myeloid translocation gene related protein 1 antibody
    • Myeloid translocation related protein 1 antibody
    • Myeloid translocation-related protein 1 antibody
    • p85 antibody
    • Protein CBFA2T2 antibody
    • ZMYND 3 antibody
    • ZMYND3 antibody
    see all

References for Anti-MTGR1 antibody [KT42] (ab53363)

This product has been referenced in:
  • Nady N  et al. ETO family protein Mtgr1 mediates Prdm14 functions in stem cell maintenance and primordial germ cell formation. Elife 4:e10150 (2015). Read more (PubMed: 26523391) »

See 1 Publication for this product

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Mouse Cell lysate - nuclear (293T)
Loading amount 25000 cells
Specification 293T
Treatment transient transfection of EGFP-Mtgr1 vector
Gel Running Conditions Non-reduced Denaturing (8%)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
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Submitted Feb 21 2008

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"