• Product nameAnti-MTH1 antibody
    See all MTH1 primary antibodies
  • Description
    Rabbit polyclonal to MTH1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length Human MTH1 Isoform p18 (NP_002443.3, amino acids 1-156).

  • Positive control
    • Human kidney tissue lysate, MTH1 transfected 293T cell lysate.



Our Abpromise guarantee covers the use of ab103615 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 18 kDa.


  • FunctionAntimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
  • Tissue specificityWidely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
  • Sequence similaritiesBelongs to the Nudix hydrolase family.
    Contains 1 nudix hydrolase domain.
  • Developmental stageIn peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
  • Post-translational
    The N-terminus is blocked.
  • Cellular localizationCytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2-hydroxy-dATP diphosphatase antibody
    • 7 8 dihydro 8 oxoguanine triphosphatase antibody
    • 7 antibody
    • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody
    • 8 oxo 7 8 dihydroguanosine triphosphatase antibody
    • 8 oxo dGTPase antibody
    • 8-dihydro-8-oxoguanine triphosphatase antibody
    • 8-oxo-dGTPase antibody
    • 8ODP_HUMAN antibody
    • MTH 1 antibody
    • MTH1 antibody
    • MutT human homolog 1 antibody
    • Nucleoside diphosphate linked moiety X motif 1 antibody
    • Nucleoside diphosphate linked moiety X type motif 1 antibody
    • Nucleoside diphosphate-linked moiety X motif 1 antibody
    • Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody
    • Nudix hydrolase 1 antibody
    • Nudix motif 1 antibody
    • Nudix type motif 1 antibody
    • NUDT 1 antibody
    • Nudt1 antibody
    see all

Anti-MTH1 antibody images

  • Anti-MTH1 antibody (ab103615) at 5 µg/ml + Human kidney tissue lysate at 50 µg

    Predicted band size : 18 kDa
  • All lanes : Anti-MTH1 antibody (ab103615) at 5 µg/ml

    Lane 1 : MTH1 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Predicted band size : 18 kDa

References for Anti-MTH1 antibody (ab103615)

This product has been referenced in:
  • Yao Y  et al. Screening and identification of potential predictive biomarkers for Down's syndrome from second trimester maternal serum. Expert Rev Proteomics 12:97-107 (2015). WB ; Human . Read more (PubMed: 25434962) »

See 1 Publication for this product

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