• Product nameAnti-MTH1 antibody
    See all MTH1 primary antibodies
  • Description
    Mouse monoclonal to MTH1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-180 of Human MTH1



Our Abpromise guarantee covers the use of ab55527 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAntimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
    • Tissue specificityWidely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
    • Sequence similaritiesBelongs to the Nudix hydrolase family.
      Contains 1 nudix hydrolase domain.
    • Developmental stageIn peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
    • Post-translational
      The N-terminus is blocked.
    • Cellular localizationCytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
    • Information by UniProt
    • Database links
    • Alternative names
      • 2-hydroxy-dATP diphosphatase antibody
      • 7 8 dihydro 8 oxoguanine triphosphatase antibody
      • 7 antibody
      • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody
      • 8 oxo 7 8 dihydroguanosine triphosphatase antibody
      • 8 oxo dGTPase antibody
      • 8-dihydro-8-oxoguanine triphosphatase antibody
      • 8-oxo-dGTPase antibody
      • 8ODP_HUMAN antibody
      • MTH 1 antibody
      • MTH1 antibody
      • MutT human homolog 1 antibody
      • Nucleoside diphosphate linked moiety X motif 1 antibody
      • Nucleoside diphosphate linked moiety X type motif 1 antibody
      • Nucleoside diphosphate-linked moiety X motif 1 antibody
      • Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody
      • Nudix hydrolase 1 antibody
      • Nudix motif 1 antibody
      • Nudix type motif 1 antibody
      • NUDT 1 antibody
      • Nudt1 antibody
      see all

    Anti-MTH1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab55527 MTH1 antibody at 1ug/ml. Predicted band size of immunogen is 46 kDa

    References for Anti-MTH1 antibody (ab55527)

    ab55527 has not yet been referenced specifically in any publications.

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