• Product name
  • Description
    Rabbit polyclonal to MTH1
  • Host species
  • Tested applications
    Suitable for: ICC/IF, IHC-P, IHC-FoFr, IHC-Fr, WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic C-terminal peptide:


    with a cysteine added for conjugation to KLH, corresponding to amino acids 143-156 of Human MTH1.

  • Positive control
    • Hela cell extracts.


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.05% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab98 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.
IHC-P Use at an assay dependent concentration. PubMed: 21538080Human Tissue
IHC-FoFr Use at an assay dependent concentration. PubMed: 21538080Mouse Tissue
IHC-Fr 1/200.
WB 1/500. Predicted molecular weight: 18 kDa.


  • Function
    Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA.
  • Tissue specificity
    Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
  • Sequence similarities
    Belongs to the Nudix hydrolase family.
    Contains 1 nudix hydrolase domain.
  • Developmental stage
    In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.
  • Post-translational
    The N-terminus is blocked.
  • Cellular localization
    Cytoplasm. Mitochondrion matrix and Cytoplasm. Mitochondrion matrix. Nucleus. Mostly present in cytoplasm. Variant Met-124 has decreased efficiency in translocation to mitochondria.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2-hydroxy-dATP diphosphatase antibody
    • 7 8 dihydro 8 oxoguanine triphosphatase antibody
    • 7 antibody
    • 8 oxo 7 8 dihydrodeoxyguanosine triphosphatase antibody
    • 8 oxo 7 8 dihydroguanosine triphosphatase antibody
    • 8 oxo dGTPase antibody
    • 8-dihydro-8-oxoguanine triphosphatase antibody
    • 8-oxo-dGTPase antibody
    • 8ODP_HUMAN antibody
    • MTH 1 antibody
    • MTH1 antibody
    • MutT human homolog 1 antibody
    • Nucleoside diphosphate linked moiety X motif 1 antibody
    • Nucleoside diphosphate linked moiety X type motif 1 antibody
    • Nucleoside diphosphate-linked moiety X motif 1 antibody
    • Nudix (nucleoside diphosphate linked moiety X) type motif 1 antibody
    • Nudix hydrolase 1 antibody
    • Nudix motif 1 antibody
    • Nudix type motif 1 antibody
    • NUDT 1 antibody
    • Nudt1 antibody
    see all


This product has been referenced in:
  • Zhang X  et al. Expression and function of MutT homolog 1 in distinct subtypes of breast cancer. Oncol Lett 13:2161-2168 (2017). IHC-P ; Human . Read more (PubMed: 28454376) »
  • Song XN  et al. Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and alzheimer's disease Patients. Neurochem Res 36:1558-65 (2011). IHC-P, IHC-FoFr ; Human, Mouse . Read more (PubMed: 21538080) »

See all 5 Publications for this product

Customer reviews and Q&As

Thank you for you enquiry. We have not tested specificity of any isoforms of MTH1. I BLASTed the immunogen sequence. Unfortunately, I did not find any information comparing sequence homology of our MTH1 and the these isoforms. I'm sorry that I c...

Read More

We have tested ab98 with whole cell lysates of HeLa. We would therefore recommend HeLa Lysate - ab7898. Good luck with your experiments!

We have tested ab98 with whole cell lysates of HeLa. We would therefore recommend HeLa Lysate - ab7898. Good luck with your experiments!


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