Overview

  • Product name
  • Description
    Rabbit polyclonal to MTHFR
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Cow
  • Immunogen

    Recombinant fragment containing a sequence corresponding to a region within amino acids 318-551 of Human MTHFR. (Uniprot: P42898)

  • Positive control
    • A549 cell lysate and HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab125707 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 75 kDa.

Target

  • Function
    Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.
  • Pathway
    One-carbon metabolism; tetrahydrofolate interconversion.
  • Involvement in disease
    Defects in MTHFR are the cause of methylenetetrahydrofolate reductase deficiency (MTHFRD) [MIM:236250]. MTHFRD is autosomal recessive disorder with a wide range of features including homocysteinuria, homocysteinemia [MIM:603174], developmental delay, severe mental retardation, perinatal death, psychiatric disturbances, and later-onset neurodegenerative disorders.
    Defects in MTHFR may be a cause of susceptibility to ischemic stroke (ISCHSTR) [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.
    Defects in MTHFR may be a cause of susceptibility to folate-sensitive neural tube defects (folate-sensitive NTD) [MIM:601634]. The most common NTDs are open spina bifida (myelomeningocele) and anencephaly.
  • Sequence similarities
    Belongs to the methylenetetrahydrofolate reductase family.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5 10 methylenetetrahydrofolate reductase (NADPH) antibody
    • 5 10 methylenetetrahydrofolate reductase antibody
    • Methylenetetrahydrofolate reductase (NAD(P)H) antibody
    • Methylenetetrahydrofolate reductase antibody
    • Methylenetetrahydrofolate reductase intermediate form antibody
    • MTHFR antibody
    • MTHR_HUMAN antibody
    see all

Images

  • Anti-MTHFR antibody (ab125707) at 1/1000 dilution + A549 cell lysate at 30 µg

    Predicted band size : 75 kDa

References

ab125707 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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