Overview

  • Product nameAnti-MTMR14 antibody
    See all MTMR14 primary antibodies
  • Description
    Rabbit polyclonal to MTMR14
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Pig
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 395-444 (NFLKHITSEE FSALKTQRRK SLPARDGGFT LEDICMLRRK DRGSTTSLGS) of Human MTMR14 (NP_001070993).

  • Positive control
    • Human fetal heart lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab102085 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 72 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionLipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
  • Tissue specificityExpressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
  • Involvement in diseaseDefects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Cellular localizationCytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C3orf29 antibody
    • Egg derived tyrosine phosphatase homolog antibody
    • FLJ11546 antibody
    • FLJ22405 antibody
    • FLJ46453 antibody
    • FLJ90311 antibody
    • HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody
    • HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody
    • hEDTP antibody
    • hJumpy antibody
    • jumpy antibody
    • MTMR 14 antibody
    • MTMR14 antibody
    • MTMRE_HUMAN antibody
    • Myotubularin related protein 14 antibody
    • Myotubularin-related protein 14 antibody
    • NS5ATP4ABP1 antibody
    see all

Anti-MTMR14 antibody images

  • Anti-MTMR14 antibody (ab102085) at 1 µg/ml + Human fetal heart lysate at 10 µg

    Predicted band size : 72 kDa

References for Anti-MTMR14 antibody (ab102085)

ab102085 has not yet been referenced specifically in any publications.

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