Overview

  • Product nameAnti-MTMR14 antibody
    See all MTMR14 primary antibodies
  • Description
    Mouse polyclonal to MTMR14
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length MTMR14 protein (Human)

  • Positive control
    • MTMR14 transfected 293T cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab67833 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 72 kDa).

Target

  • FunctionLipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
  • Tissue specificityExpressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
  • Involvement in diseaseDefects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
  • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
  • Cellular localizationCytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • C3orf29 antibody
    • Egg derived tyrosine phosphatase homolog antibody
    • FLJ11546 antibody
    • FLJ22405 antibody
    • FLJ46453 antibody
    • FLJ90311 antibody
    • HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody
    • HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody
    • hEDTP antibody
    • hJumpy antibody
    • jumpy antibody
    • MTMR 14 antibody
    • MTMR14 antibody
    • MTMRE_HUMAN antibody
    • Myotubularin related protein 14 antibody
    • Myotubularin-related protein 14 antibody
    • NS5ATP4ABP1 antibody
    see all

Anti-MTMR14 antibody images

  • All lanes : Anti-MTMR14 antibody (ab67833) at 1/500 dilution

    Lane 1 : MTMR14 transfected 293T cell lysate
    Lane 2 : Non-transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 72 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)

References for Anti-MTMR14 antibody (ab67833)

ab67833 has not yet been referenced specifically in any publications.

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