Overview

  • Product nameAnti-MTMR14 antibody
    See all MTMR14 primary antibodies
  • Description
    Rabbit polyclonal to MTMR14
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Cow
  • Immunogen

    Synthetic peptide conjugated to KLH derived from within residues 600 to the C-terminus of Human MTMR14.

    (Peptide available as ab92660.)

  • Positive control
    • This antibody gave a positive signal in the following whole cell lysates: HEK293; HepG2; A549.

Properties

Applications

Our Abpromise guarantee covers the use of ab76952 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1 µg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 72 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionLipid phosphatase which efficiently dephosphorylates phosphatidylinositol 3-phosphate (PtdIns3P) and PtdIns(3,5)P2; inactive toward PtdIns4P, PtdIns(3,4)P2, PtdIns(4,5)P2 and PtdIns(3,4,5)P3.
    • Tissue specificityExpressed in various tissues, including heart, skeletal muscle, placenta, liver, lung, kidney and pancreas.
    • Involvement in diseaseDefects in MTMR14 may be a cause of centronuclear myopathy autosomal dominant (ADCNM) [MIM:160150]; also known as autosomal dominant myotubular myopathy. Centronuclear myopathies are congenital muscle disorders characterized by progressive muscular weakness and wasting involving mainly limb girdle, trunk, and neck muscles. It may also affect distal muscles. Weakness may be present during childhood or adolescence or may not become evident until the third decade of life. Ptosis is a frequent clinical feature. The most prominent histopathologic features include high frequency of centrally located nuclei in muscle fibers not secondary to regeneration, radial arrangement of sarcoplasmic strands around the central nuclei, and predominance and hypotrophy of type 1 fibers.
    • Sequence similaritiesBelongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
    • Cellular localizationCytoplasm. Found in reticular structures and plasma membrane ruffles. Concentrated near the nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • C3orf29 antibody
      • Egg derived tyrosine phosphatase homolog antibody
      • FLJ11546 antibody
      • FLJ22405 antibody
      • FLJ46453 antibody
      • FLJ90311 antibody
      • HCV NS5A transactivated protein 4 splice variant A binding protein 1 antibody
      • HCV NS5A-transactivated protein 4 splice variant A-binding protein 1 antibody
      • hEDTP antibody
      • hJumpy antibody
      • jumpy antibody
      • MTMR 14 antibody
      • MTMR14 antibody
      • MTMRE_HUMAN antibody
      • Myotubularin related protein 14 antibody
      • Myotubularin-related protein 14 antibody
      • NS5ATP4ABP1 antibody
      see all

    Anti-MTMR14 antibody images

    • All lanes : Anti-MTMR14 antibody (ab76952) at 1 µg/ml

      Lane 1 : HEK293 (Human embryonic kidney cell line) Whole Cell Lysate
      Lane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
      Lane 3 : A549 (Human lung adenocarcinoma epithelial cell line) Whole Cell Lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution
      Developed using the ECL technique

      Performed under reducing conditions.

      Predicted band size : 72 kDa
      Observed band size : 90 kDa (why is the actual band size different from the predicted?)


      Exposure time : 20 minutes

    References for Anti-MTMR14 antibody (ab76952)

    ab76952 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab76952.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"