Overview

  • Product name
  • Description
    Rabbit polyclonal to MTMR2
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Chicken, Cow
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 417-643 of Human MTMR2 (UniProt ID: Q13614).

  • Positive control
    • NT2D1 and U-87 MG whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab155678 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 73 kDa.

Target

  • Function
    Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol-3-phosphate and phosphatidylinositol-3,5-bisphosphate.
  • Involvement in disease
    Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:601382]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
  • Sequence similarities
    Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
    Contains 1 GRAM domain.
    Contains 1 myotubularin phosphatase domain.
  • Domain
    The coiled-coil domain mediates interaction with SBF2.
  • Cellular localization
    Cytoplasm. Membrane. Partly associated with membranes.
  • Information by UniProt
  • Database links
  • Alternative names
    • CMT4B antibody
    • CMT4B1 antibody
    • KIAA1073 antibody
    • MTMR2 antibody
    • MTMR2_HUMAN antibody
    • Myotubularin related protein 2 antibody
    • Myotubularin-related protein 2 antibody
    • OTTHUMP00000204445 antibody
    • OTTHUMP00000204446 antibody
    • OTTHUMP00000204447 antibody
    • OTTHUMP00000204448 antibody
    • Phosphatidylinositol 3 phosphate phosphatase antibody
    • Phosphatidylinositol 3,5 bisphosphate 3 phosphatase antibody
    see all

Images

  • Anti-MTMR2 antibody (ab155678) at 1/1000 dilution + U-87 MG whole cell lysate at 30 µg

    Predicted band size: 73 kDa



    7.5% SDS PAGE

References

ab155678 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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