Anti-mTOR (phospho S2448) antibody [EPR426(2)] (ab109268)

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ab109268 has been referenced in 44 publications.

  • Lin Q  et al. Cisplatin regulates cell autophagy in endometrial cancer cells via the PI3K/AKT/mTOR signalling pathway. Oncol Lett 13:3567-3571 (2017). PubMed: 28521459
  • Zhang D  et al. Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway. Int J Oncol 50:1513-1530 (2017). WB ; Human . PubMed: 28339091
  • Li H  et al. MEN1/Menin regulates milk protein synthesis through mTOR signaling in mammary epithelial cells. Sci Rep 7:5479 (2017). PubMed: 28710500
  • Cao Y  et al. Ginsenoside Rg3 inhibits angiogenesis in a rat model of endometriosis through the VEGFR-2-mediated PI3K/Akt/mTOR signaling pathway. PLoS One 12:e0186520 (2017). PubMed: 29140979
  • Guo JN  et al. Activation of the Akt/mTOR signaling pathway: A potential response to long-term neuronal loss in the hippocampus after sepsis. Neural Regen Res 12:1832-1842 (2017). IHC-P ; Mouse . PubMed: 29239329
  • Prieto-Domínguez N  et al. Melatonin enhances sorafenib actions in human hepatocarcinoma cells by inhibiting mTORC1/p70S6K/HIF-1a and hypoxia-mediated mitophagy. Oncotarget 8:91402-91414 (2017). PubMed: 29207653
  • Zeng X  et al. Acylated and unacylated ghrelin inhibit atrophy in myotubes co-cultured with colon carcinoma cells. Oncotarget 8:72872-72885 (2017). PubMed: 29069832
  • Wu J  et al. High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction. Oncotarget 8:40843-40856 (2017). PubMed: 28489581
  • Fang Y  et al. TFE3 regulates renal adenocarcinoma cell proliferation via activation of the mTOR pathway. Mol Med Rep 16:2721-2725 (2017). PubMed: 28713889
  • Song B  et al. Beclin 1 overexpression inhibits chondrocyte apoptosis and downregulates extracellular matrix metabolism in osteoarthritis. Mol Med Rep 16:3958-3964 (2017). PubMed: 28731147
  • Zou B  et al. Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3. Oncol Rep 38:1431-1441 (2017). PubMed: 28714011
  • Li Z  et al. Anti-Oxidative Stress Activity Is Essential for Amanita caesarea Mediated Neuroprotection on Glutamate-Induced Apoptotic HT22 Cells and an Alzheimer's Disease Mouse Model. Int J Mol Sci 18:N/A (2017). PubMed: 28749416
  • Yang L  et al. The role of mTOR signaling pathway on cognitive functions in cerebral ischemia-reperfusion. Exp Ther Med 14:2839-2844 (2017). PubMed: 28912846
  • Liang Y  et al. MicroRNA-320 regulates autophagy in retinoblastoma by targeting hypoxia inducible factor-1a. Exp Ther Med 14:2367-2372 (2017). PubMed: 28962169
  • Zhu H  et al. IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced. PLoS One 12:e0169038 (2017). WB ; Human . PubMed: 28052098
  • Huang G  et al. Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway. Int J Mol Med 39:559-568 (2017). Human . PubMed: 28112381
  • Wang Z  et al. Clinicopathological signature of p21-activated kinase 1 in prostate cancer and its regulation of proliferation and autophagy via the mTOR signaling pathway. Oncotarget 8:22563-22580 (2017). WB, IHC-P ; Human . PubMed: 28186966
  • Tian Y  et al. Activation of Transient Receptor Potential Vanilloid 4 Impairs the Dendritic Arborization of Newborn Neurons in the Hippocampal Dentate Gyrus through the AMPK and Akt Signaling Pathways. Front Mol Neurosci 10:190 (2017). WB ; Mouse . PubMed: 28663724
  • Wang Z  et al. Knockdown of STMN1 enhances osteosarcoma cell chemosensitivity through inhibition of autophagy. Oncol Lett 13:3465-3470 (2017). PubMed: 28529574
  • Fu S  et al. Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity. Sci Rep 7:43771 (2017). PubMed: 28256562
  • Li Y  et al. MicroRNA-210 induces endothelial cell apoptosis by directly targeting PDK1 in the setting of atherosclerosis. Cell Mol Biol Lett 22:3 (2017). WB . PubMed: 28536634
  • Wang J  et al. Investigations on the antifatigue and antihypoxic effects of Paecilomyces hepiali extract. Mol Med Rep 13:1861-8 (2016). PubMed: 26717979
  • Yang Z  et al. Infiltrating macrophages increase RCC epithelial mesenchymal transition (EMT) and stem cell-like populations via AKT and mTOR signaling. Oncotarget 7:44478-44491 (2016). PubMed: 27283897
  • Chen Y  et al. FGFR antagonist induces protective autophagy in FGFR1-amplified breast cancer cell. Biochem Biophys Res Commun N/A:N/A (2016). WB ; Human . PubMed: 26993162
  • Gao B  et al. Eicosapentaenoic acid attenuates dexamethasome-induced apoptosis by inducing adaptive autophagy via GPR120 in murine bone marrow-derived mesenchymal stem cells. Cell Death Dis 7:e2235 (2016). WB ; Mouse . PubMed: 27228350
  • Zhang L  et al. Reprogramming towards anabolism impedes degeneration in a preclinical model of retinitis pigmentosa. Hum Mol Genet N/A:N/A (2016). PubMed: 27516389
  • Fan G  et al. Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. J Cell Mol Med 20:1908-19 (2016). Rat . PubMed: 27385290
  • Yao CJ  et al. Activation of p53/miR-34a Tumor Suppressor Axis by Chinese Herbal Formula JP-1 in A549 Lung Adenocarcinoma Cells. Evid Based Complement Alternat Med 2016:5989681 (2016). WB ; Human . PubMed: 28074102
  • Li XJ  et al. Bergapten exerts inhibitory effects on diabetes-related osteoporosis via the regulation of the PI3K/AKT, JNK/MAPK and NF-?B signaling pathways in osteoprotegerin knockout mice. Int J Mol Med N/A:N/A (2016). WB ; Mouse . PubMed: 27840967
  • Sun H  et al. Resistance of glioma cells to nutrient-deprived microenvironment can be enhanced by CD133-mediated autophagy. Oncotarget 7:76238-76249 (2016). WB ; Rat . PubMed: 27780926
  • Wiersma VR  et al. The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux. Autophagy 11:1373-88 (2015). WB . PubMed: 26086204
  • Perez SE  et al. Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aß and tau pathology. J Neuropathol Exp Neurol 74:345-58 (2015). PubMed: 25756588
  • Duan Y  et al. Effects of tonic immobility (TI) and corticosterone (CORT) on energy status and protein metabolism in pectoralis major muscle of broiler chickens. Comp Biochem Physiol A Mol Integr Physiol 169:90-5 (2014). Chicken . PubMed: 24389091
  • Vallejo D  et al. Autophagic response in the Rabbit Hemorrhagic Disease, an animal model of virally-induced fulminant hepatic failure. Vet Res 45:15 (2014). WB ; Rabbit . PubMed: 24490870
  • Li C  et al. Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. PLoS One 9:e101526 (2014). WB ; Human . PubMed: 24992302
  • Chikh A  et al. iASPP is a novel autophagy inhibitor in keratinocytes. J Cell Sci 127:3079-93 (2014). PubMed: 24777476
  • Chen Y  et al. Shikonin inhibits prostate cancer cells metastasis by reducing matrix metalloproteinase-2/-9 expression via AKT/mTOR and ROS/ERK1/2 pathways. Int Immunopharmacol 21:447-55 (2014). PubMed: 24905636
  • Picard M  et al. Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. Proc Natl Acad Sci U S A 111:E4033-42 (2014). WB . PubMed: 25192935
  • Chung CH  et al. Butein Inhibits Angiogenesis of Human Endothelial Progenitor Cells via the Translation Dependent Signaling Pathway. Evid Based Complement Alternat Med 2013:943187 (2013). WB ; Rat . PubMed: 23840271
  • Xu MY  et al. Akebia saponin PA induces autophagic and apoptotic cell death in AGS human gastric cancer cells. Food Chem Toxicol 59:703-8 (2013). Human . PubMed: 23850994
  • Hao J  et al. Phospho-mTOR: a novel target in regulation of renal lipid metabolism abnormality of diabetes. Exp Cell Res 319:2296-306 (2013). Rat . PubMed: 23827786
  • Liu SC  et al. Leukemia inhibitory factor promotes nasopharyngeal carcinoma progression and radioresistance. J Clin Invest 123:5269-83 (2013). IHC ; Human . PubMed: 24270418
  • Peng YF  et al. Autophagy inhibition suppresses pulmonary metastasis of HCC in mice via impairing anoikis resistance and colonization of HCC cells. Autophagy 9:2056-68 (2013). WB ; Human . PubMed: 24157892
  • Wang XQ  et al. The differential proliferative ability of satellite cells in Lantang and Landrace pigs. PLoS One 7:e32537 (2012). WB ; Pig . PubMed: 22427853


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