Overview

  • Product name
  • Description
    Rabbit polyclonal to MTUS1
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog
  • Immunogen

    A 14-22 amino acid region within synthetic peptide: EALTVVIQHL LSEREEALKQ HKTLSQELVN LRGELVTAST TCEKLEKARN, corresponding to internal sequence amino acids 181-230 of Human MTUS1

  • Positive control
    • Jurkat cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab61309 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1.25 µg/ml. Detects a band of approximately 44 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • Relevance
    Multiple alternatively spliced transcript variants encoding different isoforms have been found for the MTUS1 (Mitochondrial tumor suppressor 1) gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and cooperates with the angiotension II (AT2) receptor (AGTR2) to inhibit ERK2 activation and cell proliferation. MTUS1 polypeptides are identical in their carboxy-terminal region carrying four coiled-coil domains. In their amino-terminal portion, MTUS1 polypeptides exhibit distinct motifs for localisation in the cytosol, nucleus or cell membrane, suggesting that MTUS1 gene products may be involved in a variety of intracellular functions in an AT2-dependent and independent manner.
  • Cellular localization
    Cell Membrane, Golgi Apparatus, Mitochondrial and Nuclear. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II.
  • Database links
  • Alternative names
    • AGTR2-interacting protein antibody
    • Angiotensin II type 2 receptor interacting protein antibody
    • AT2 receptor interacting protein antibody
    • AT2 receptor-binding protein antibody
    • AT2R binding protein antibody
    • ATBP antibody
    • ATIP antibody
    • ATIP1 antibody
    • DKFZp586D1519 antibody
    • DKFZp686F20243 antibody
    • Erythroid differentiation related antibody
    • FLJ14295 antibody
    • GK 1 antibody
    • GK1 antibody
    • KIAA1288 antibody
    • Microtubule associated tumor suppressor 1 antibody
    • Mitochondrial tumor suppressor 1 antibody
    • Mitochondrial tumor suppressor gene 1 antibody
    • MP 44 antibody
    • MP44 antibody
    • MTSG 1 antibody
    • MTSG1 antibody
    • MTUS 1 antibody
    • Transcription factor MTSG1 antibody
    see all

Images

  • Anti-MTUS1 antibody (ab61309) at 1.25 µg/ml + Jurkat cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Observed band size : 44 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-MTUS1 antibody (ab61309) at 1/200 dilution

    Lane 1 : Whole cell lysate prepared from MCF cells transfected with GFP-ATIP1
    Lane 2 : Whole cell lysate prepared from MCF cells transfected with GFP-ATIP3
    Lane 3 : Whole cell lysate prepared from MCF cells transfected with GFP

References

ab61309 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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