Overview

  • Product name
    MU-GLU
  • Description
    Fluorogenic beta-glucosidase substrate.
  • Alternative names
    • 4-Methylumbelliferyl-beta-D-glucoside
    • 4-MU-beta-D-Glc
    • 4-MU-GLU
    • 4-MUG
    • MUD
    see all
  • Biological description

    Fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). Used for characterizing novel β-glucosidases. Also used in assays to evaluate deficiency in β-glucocerebrosidase activity related to Gaucher disease. Hydrolysis releases the fluorescent product 4-MU.


    Fluorescence: λex 365 nm; λem 445 nm in 0.1 M sodium acetate pH 5.0 (after cleavage by β-glucosidase).

  • Purity
    > 99%

Properties

  • Molecular weight
    338.32
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C16H18O8
  • CAS Number
    18997-57-4
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Hernández-Guzmán A  et al. Purification and characterization of an extracellular ß-glucosidase from Sporothrix schenckii. FEBS Open Bio 6:1067-1077 (2016). Read more (PubMed: 27833847) »
  • Shanmuganathan M & Britz-McKibbin P Inhibitor screening of pharmacological chaperones for lysosomal ß-glucocerebrosidase by capillary electrophoresis. Anal Bioanal Chem 399:2843-53 (2011). Read more (PubMed: 21286689) »
  • Kämpfer P  et al. Glycosidase profiles of members of the family Enterobacteriaceae. J Clin Microbiol 29:2877-9 (1991). Read more (PubMed: 1757564) »
  • Panosian KJ & Edberg SC Rapid identification of Streptococcus bovis by using combination constitutive enzyme substrate hydrolyses. J Clin Microbiol 27:1719-22 (1989). Read more (PubMed: 2570081) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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