Anti-Mu Opioid Receptor splice variant antibody (ab10306)

Overview

  • Product name
    Anti-Mu Opioid Receptor splice variant antibody
  • Description
    Rabbit polyclonal to Mu Opioid Receptor splice variant
  • Tested applications
    Suitable for: IHC-Frmore details
  • Species reactivity
    Reacts with: Mouse, Rat
  • Immunogen

    Synthetic peptide:

    KSCMDRGMRNLLPDDGPRQE

    .

  • General notes


    The powerful effects of opiate are mediated through the opioid receptors located on the plasma membrane of neurons and other peripheral cells. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile. The mu opioid receptor is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.05% Sodium Azide
    Constituents: Whole Serum
  • Purity
    Whole antiserum
  • Primary antibody notes
    The powerful effects of opiate are mediated through the opioid receptors located on the plasma membrane of neurons and other peripheral cells. There are at least 3 types of opioid receptors, mu, kappa, and delta, each with a distinct pharmacologic profile. The mu opioid receptor is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab10306 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/5000 - 1/10000.

Target

  • Relevance
    Three types of opioid receptors have been cloned: mu, delta, and kappa. Opioid receptors are seven transmembrane G-protein coupled receptors. They share a high degree of homology and are most divergent at the N- and C-termini. Activation of mu opioid receptors leads to a decrease in neuronal excitability. Most actions of exogenous opioids, such as morphine, are mediated through the µ-opioid receptor, including analgesia, tolerance and reward.
  • Cellular localization
    Cell Membrane
  • Database links
  • Alternative names
    • mor antibody
    • Mu opioid receptor antibody
    • Mu opioid receptor variant C antibody
    • Opioid receptor mu 1 antibody
    • Oprm antibody
    see all

Images

  • ab10306 at 1/5000-1/10000 dilution staining Mu Opioid Receptor in rat spinal cord dorsal horn by Immunohistochemistry.

References

ab10306 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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