Overview

  • Product nameAnti-MUC12 antibody
  • Description
    Rabbit polyclonal to MUC12
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 5248-5367 of Human MUC12 (Q9UKN1)

  • Positive control
    • Human adrenal gland tissue

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab121777 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • RelevanceHuman MUC12 (Mucin 12) is a novel mucin of epithelial mucins, which are large, secreted or cell surface glycoproteins involved in epithelial cell protection, adhesion modulation, and signaling. Using differential display on RNA from paired normal colonic mucosa and primary colorectal tumor, MUC12 is identified as one of the 2 partial cDNAs representing novel mucin genes as well as MUC11. They are downregulated in colorectal tumors.The deduced MUC12 protein contains a predicted transmembrane domain, 2 extracellular cysteine-rich EGF-like domains, a coiled-coil region, and a domain consisting of serine-, threonine-, and proline-rich degenerate tandem repeats of 28 amino acids, a structural feature typical of mucins. Human MUC12 shares high sequence homology with MUC3 and MUC4 . Northern blot analysis of 50 different normal tissues detected MUC12 expression in colon, pancreas, prostate, and uterus, with highest expression in colon. The MUC12 transcript is large, estimated to be longer than 12 kb. Expression of MUC12 was downregulated or absent in 6 of 15 (40%) colorectal tumors, as compared with matched normal colonic tissues. MUC12 expression was not detected in any of 6 colorectal cancer cell lines examined.
  • Cellular localizationCell Membrane
  • Database links
  • Alternative names
    • MUC11 antibody
    • MUC12 antibody
    • Mucin 12 antibody
    • Mucin-12 antibody

Anti-MUC12 antibody images

  • ab121777 at a 1/50 dilution staining MUC12 in Human adrenal gland tissue (paraffin embedded) by immunohistochemistry.

References for Anti-MUC12 antibody (ab121777)

ab121777 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab121777.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"