Anti-MUC7 antibody [4D2-1D7] (ab105466)

Overview

  • Product nameAnti-MUC7 antibody [4D2-1D7]
    See all MUC7 primary antibodies
  • Description
    Mouse monoclonal [4D2-1D7] to MUC7
  • SpecificityNo cross reactivity with other Human mucins.
  • Tested applicationsSuitable for: ELISA, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    EGRERDHELRHRRHHHQ

    conjugated to KLH, corresponding to N terminal amino acids 21-37 of Human MUC7

  • General notesGrowth Conditions: Cell were grown in IMDM medium containing hypoxanthine, aminopterin, thymidine, 20% FCS and 10% Domadrive.

Properties

Applications

Our Abpromise guarantee covers the use of ab105466 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration.
WB Use at an assay dependent concentration. Predicted molecular weight: 39 kDa.

Target

  • FunctionMay function in a protective capacity by promoting the clearance of bacteria in the oral cavity and aiding in mastication, speech, and swallowing. Binds P.aeruginosa pili.
  • Tissue specificityExpressed in salivary gland tissues and only in those that contain mucous acinar cells (e.g. sublingual and submandibular glands) and not in salivary glands containing only serous acinar cells (e.g. parotid gland).
  • Involvement in diseaseGenetic variations in MUC7 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
  • Post-translational
    modifications
    N- and O-glycosylated. Contains fucose, mannose, galactose, N-acetylglucosamine and N-acetylgalactosamine.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Apo MG2 antibody
    • Apo-MG2 antibody
    • DKFZp686J03256 antibody
    • FLJ27047 antibody
    • MG2 antibody
    • MGC34772 antibody
    • MUC 7 antibody
    • MUC-7 antibody
    • MUC7 antibody
    • MUC7_HUMAN antibody
    • Mucin 7 antibody
    • Mucin 7, salivary antibody
    • Mucin 7, secreted antibody
    • Mucin-7 antibody
    • Salivary mucin 7 antibody
    • Salivary mucin-7 antibody
    see all

References for Anti-MUC7 antibody [4D2-1D7] (ab105466)

ab105466 has not yet been referenced specifically in any publications.

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