FunctionInvolved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
Sequence similaritiesBelongs to the MUM1 family. Contains 1 PWWP domain.
DomainThe PWWP domain mediates the interaction with nucleosomes.
Post-translational modificationsPhosphorylated upon DNA damage, probably by ATM or ATR.
Cellular localizationNucleus. Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1.
Detection of MUM1 in Immunoprecipitates of 293T whole cell lysates (1 mg for IP, 20% of IP loaded) using ab118808 at 6 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot detection. Detection: Chemiluminescence with an exposure time of 30 seconds.
References for Anti-MUM1 antibody (ab118808)
has not yet been referenced specifically in any publications.
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