Overview

  • Product name
    Anti-MUM1 antibody
    See all MUM1 primary antibodies
  • Description
    Rabbit polyclonal to MUM1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment within Human MUM1 aa 218-451. The exact sequence is proprietary.
    Database link: Q15306

  • Positive control
    • NCI-H929 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab183861 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 52 kDa.

Target

  • Function
    Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells.
  • Tissue specificity
    Lymphoid cells.
  • Involvement in disease
    Defects in IRF4 are a cause of multiple myeloma (MM) [MIM:254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IRF4 is found in multiple myeloma. Translocation t(6;14)(p25;q32) with the IgH locus.
  • Sequence similarities
    Belongs to the IRF family.
    Contains 1 IRF tryptophan pentad repeat DNA-binding domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
    • Alternative names
      • Interferon regulatory factor 4 antibody
      • IRF 4 antibody
      • IRF-4 antibody
      • Irf4 antibody
      • IRF4_HUMAN antibody
      • LSIRF antibody
      • Lymphocyte specific interferon regulatory factor antibody
      • Lymphocyte specific IRF antibody
      • Lymphocyte-specific interferon regulatory factor antibody
      • Multiple myeloma oncogene 1 antibody
      • MUM 1 antibody
      • MUM1 antibody
      • NF EM5 antibody
      • NF-EM5 antibody
      • NFEM5 antibody
      • PU.1 interaction partner antibody
      • Sfpi1/PU.1 interaction partner antibody
      • Transcriptional activator PIP antibody
      see all

    Images

    • Western blot - Anti-MUM1 antibody (ab183861)
      Western blot - Anti-MUM1 antibody (ab183861)
      Anti-MUM1 antibody (ab183861) at 1/1000 dilution + NCI-H929 whole cell lysate/extract at 30 µg

      Predicted band size: 52 kDa

    References

    ab183861 has not yet been referenced specifically in any publications.

    Publishing research using ab183861? Please let us know so that we can cite the reference in this datasheet.

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