Overview

  • Product nameAnti-Munc18-1 antibody
    See all Munc18-1 primary antibodies
  • Description
    Goat polyclonal to Munc18-1
  • SpecificityThis antibody is expected to recognize isoform a (NP_003156.1).
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide:

    C-SRVSFEDQAPTME

    , corresponding to C terminal amino acids 591-603 of Human Munc18

  • Positive control
    • Human Brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab52011 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 75 kDa (predicted molecular weight: 68 kDa).
IHC-P Use a concentration of 5 - 10 µg/ml.

Target

  • FunctionMay participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
  • Tissue specificityBrain and spinal cord. Highly enriched in axons.
  • Involvement in diseaseDefects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
  • Sequence similaritiesBelongs to the STXBP/unc-18/SEC1 family.
  • Cellular localizationCytoplasm. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ37475 antibody
    • Munc 18 1 antibody
    • Munc 18a antibody
    • MUNC18 1 antibody
    • N-Sec1 antibody
    • Neuronal SEC1 antibody
    • NSec1 antibody
    • p67 antibody
    • Protein unc-18 homolog 1 antibody
    • Protein unc-18 homolog A antibody
    • Rb sec1 antibody
    • RBSEC1 antibody
    • STXB1_HUMAN antibody
    • STXBP1 antibody
    • Syntaxin binding protein 1 antibody
    • Syntaxin-binding protein 1 antibody
    • Unc 18 homolog antibody
    • Unc 18A antibody
    • Unc-18A antibody
    • Unc18 1 antibody
    • UNC18 antibody
    • Unc18-1 antibody
    see all

Anti-Munc18-1 antibody images

  • Anti-Munc18-1 antibody (ab52011) at 0.1 µg/ml + Human Brain lysate (35µg protein in RIPA buffer)

    Predicted band size : 68 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)
  • ab52011 at 5 µg/ml staining Munc18 in Human cortex tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). eamed antigen retrieval with citrate buffer pH 6, AP-staining.

References for Anti-Munc18-1 antibody (ab52011)

ab52011 has not yet been referenced specifically in any publications.

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