Overview

  • Product nameAnti-Munc18-1 antibody
    See all Munc18-1 primary antibodies
  • Description
    Mouse monoclonal to Munc18-1
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: VYLITPSEKS VHSLISDFKD PPTAKYRAAH VFFTDSCPDA LFNELVKSRA AKVIKTLTEI NIAFLPYESQ VYSLDSADSF QSFYSPHKAQ MKNPI, corresponding to amino acids 74-169 of Human Munc18

Properties

Applications

Our Abpromise guarantee covers the use of ab57847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
  • Application notesWB: Use at a concentration of 1-5 µg/ml.
    IHC-P: Use at a concentration of 3 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMay participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
    • Tissue specificityBrain and spinal cord. Highly enriched in axons.
    • Involvement in diseaseDefects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
    • Sequence similaritiesBelongs to the STXBP/unc-18/SEC1 family.
    • Cellular localizationCytoplasm. Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ37475 antibody
      • Munc 18 1 antibody
      • Munc 18a antibody
      • MUNC18 1 antibody
      • N-Sec1 antibody
      • Neuronal SEC1 antibody
      • NSec1 antibody
      • p67 antibody
      • Protein unc-18 homolog 1 antibody
      • Protein unc-18 homolog A antibody
      • Rb sec1 antibody
      • RBSEC1 antibody
      • STXB1_HUMAN antibody
      • STXBP1 antibody
      • Syntaxin binding protein 1 antibody
      • Syntaxin-binding protein 1 antibody
      • Unc 18 homolog antibody
      • Unc 18A antibody
      • Unc-18A antibody
      • Unc18 1 antibody
      • UNC18 antibody
      • Unc18-1 antibody
      see all

    Anti-Munc18-1 antibody images

    • Munc18 antibody (ab57847) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human cerebellum.


    • Predicted band size : 68 kDa
      Munc18 antibody (ab57847) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-Munc18-1 antibody (ab57847)

    ab57847 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"