Recombinant
RabMAb

Anti-Munc18-1 antibody [EPR4849] (ab109023)

Overview

  • Product name
    Anti-Munc18-1 antibody [EPR4849]
    See all Munc18-1 primary antibodies
  • Description
    Rabbit monoclonal [EPR4849] to Munc18-1
  • Tested applications
    Suitable for: WB, IP, ICC/IFmore details
    Unsuitable for: Flow Cyt or IHC-P
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    A synthetic peptide corresponding to residues in Human Munc18.

  • Positive control
    • SH SY5Y and Human fetal brain lysates; SH SY5Y cells.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

Applications

Our Abpromise guarantee covers the use of ab109023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 68 kDa.
IP 1/10 - 1/100.
ICC/IF 1/100 - 1/250.
  • Application notes
    Is unsuitable for Flow Cyt or IHC-P.
  • Target

    • Function
      May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
    • Tissue specificity
      Brain and spinal cord. Highly enriched in axons.
    • Involvement in disease
      Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
    • Sequence similarities
      Belongs to the STXBP/unc-18/SEC1 family.
    • Cellular localization
      Cytoplasm. Membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • FLJ37475 antibody
      • Munc 18 1 antibody
      • Munc 18a antibody
      • MUNC18 1 antibody
      • N-Sec1 antibody
      • Neuronal SEC1 antibody
      • NSec1 antibody
      • p67 antibody
      • Protein unc-18 homolog 1 antibody
      • Protein unc-18 homolog A antibody
      • Rb sec1 antibody
      • RBSEC1 antibody
      • STXB1_HUMAN antibody
      • STXBP1 antibody
      • Syntaxin binding protein 1 antibody
      • Syntaxin-binding protein 1 antibody
      • Unc 18 homolog antibody
      • Unc 18A antibody
      • Unc-18A antibody
      • Unc18 1 antibody
      • UNC18 antibody
      • Unc18-1 antibody
      see all

    Images

    • All lanes : Anti-Munc18-1 antibody [EPR4849] (ab109023) at 1/1000 dilution

      Lane 1 : SH SY5Y cell lysate
      Lane 2 : Human fetal brain lysate

      Lysates/proteins at 10 µg per lane.


      Predicted band size : 68 kDa
    • ab109023 at 1/100 dilution staining Munc18 in SH SY5Y cells by Immunofluorescence.

    References

    ab109023 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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