Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab4982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Additional notes


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and Munc 18, catalog ab3451. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

General Info

  • Alternative names
    • FLJ37475
    • Munc 18 1
    • Munc 18a
    • MUNC18 1
    • N-Sec1
    • Neuronal SEC1
    • NSec1
    • p67
    • Protein unc-18 homolog 1
    • Protein unc-18 homolog A
    • Rb sec1
    • RBSEC1
    • STXB1_HUMAN
    • STXBP1
    • Syntaxin binding protein 1
    • Syntaxin-binding protein 1
    • Unc 18 homolog
    • Unc 18A
    • Unc-18A
    • UNC18
    • Unc18 1
    • Unc18-1
    see all
  • Function
    May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
  • Tissue specificity
    Brain and spinal cord. Highly enriched in axons.
  • Involvement in disease
    Defects in STXBP1 are the cause of epileptic encephalopathy early infantile type 4 (EIEE4) [MIM:612164]. Affected individuals have neonatal or infantile onset of seizures, suppression-burst pattern on EEG, profound mental retardation, and MRI evidence of hypomyelination.
  • Sequence similarities
    Belongs to the STXBP/unc-18/SEC1 family.
  • Cellular localization
    Cytoplasm. Membrane.
  • Information by UniProt

References

ab4982 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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