E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.
Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
Protein modification; protein ubiquitination.
Contains 1 B box-type zinc finger. Contains 1 COS domain. Contains 1 RING-type zinc finger.
Expressed throughout all developmental stages.
The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity.
Cytoplasm. Nucleus. Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes.
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue labeling MURF1 using ab183094 at a 1/60 dilution, Image on the right is treated with the synthetic peptide (original magnification: ×200).