Overview

Description

  • Nature
    Synthetic
  • Amino Acid Sequence

    Associated products

    Specifications

    Our Abpromise guarantee covers the use of ab178003 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    • Applications

      Blocking - Blocking peptide for Anti-Musashi 1 / Msi1 antibody [EP1302] (ab52865)

    • Form
      Liquid
    • Additional notes

      - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
      - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
      - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
      - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
      - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

    • Concentration information loading...

    Preparation and Storage

    • Stability and Storage

      Shipped at 4°C. Store at -20°C.

    General Info

    • Alternative names
      • Msi 1
      • Msi1
      • MSI1H_HUMAN
      • Musashi homolog 1
      • Musashi RNA binding protein 1
      • Musashi-1
      • Musashi1
      • RNA binding protein Musashi homolog 1
      • RNA-binding protein Musashi homolog 1
      see all
    • Function
      RNA binding protein that regulates the expression of target mRNAs at the translation level. Regulates expression of the NOTCH1 antagonist NUMB. Binds RNA containing the sequence 5'-GUUAGUUAGUUAGUU-3' and other sequences containing the pattern 5'-[GA]U(1-3)AGU-3'. May play a role in the proliferation and maintenance of stem cells in the central nervous system.
    • Tissue specificity
      Detected in fetal kidney, brain, liver and lung, and in adult brain and pancreas. Detected in hepatoma cell lines.
    • Sequence similarities
      Belongs to the Musashi family.
      Contains 2 RRM (RNA recognition motif) domains.
    • Domain
      The first RNA recognition motif binds more strongly to RNA compared to the second one.
    • Cellular localization
      Cytoplasm. Nucleus.
    • Information by UniProt

    References

    ab178003 has not yet been referenced specifically in any publications.

    Publishing research using ab178003? Please let us know so that we can cite the reference in this datasheet.

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