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Products:Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Muscarinic Receptors
Overview
Product name
Anti-muscarinic Acetylcholine Receptor 1 antibody
See all Muscarinic Acetylcholine Receptor 1 products (4) ...
Description
Rabbit polyclonal to muscarinic Acetylcholine Receptor 1
Specificity
Detects recombinant mouse Muscarinic Acetylcholine Receptor 1 (m1AChR).
Tested applications
Cross reactivity
Reacts with
Mouse
Predicted to work with
Rat, Human
Immunogen
Fusion protein containing amino acids 269-320 from human m1 AChR. This sequence is completely conserved in mouse, rat, and bovine protein.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, 1 mg/ml BSA, 0.05% sodium azide
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Primary antibody notes
Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine. The mAChRs are present in neurons of the central and peripheral nervous systems, cardiac and smooth muscle and various exocrine glands. There are 5 subtypes (m1-m5) of the receptor that have a tissue specific pattern of expression. The m1 receptor is localized primarily in brain tissue.
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Acetylcholine
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Muscarinic Receptors
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Western blot - muscarinic Acetylcholine Receptor 1 antibody (ab3480)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3480 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 2 µg/ml
Application notes
Is unsuitable for or IHC-P.
Target
Relevance
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. Muscarinic receptors are so called as they are more sensitive to the effects of the alkaloid muscarine, rather than nicotine.
Cellular localization
Cell Membrane; multi-pass membrane protein
Alternative names
- Cholinergic receptor muscarinic 1 antibody
- CHRM 1 antibody
- CHRM1 antibody
see all
Database links
- Entrez Gene: 1128 Human
- Entrez Gene: 12669 Mouse
- Entrez Gene: 25229 Rat
- Omim: 118510 Human
- SwissProt: P11229 Human
- SwissProt: P12657 Mouse
- SwissProt: P08482 Rat
Anti-muscarinic Acetylcholine Receptor 1 antibody images:
Western blot - muscarinic Acetylcholine Receptor 1 antibody (ab3480)
Western blot detection of recombinant m1AChR using ab3480
References for Anti-muscarinic Acetylcholine Receptor 1 antibody (ab3480)
ab3480 has not yet been referenced specifically in any publications.
Publishing research using ab3480? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"