muscarinic Acetylcholine Receptor 1 antibody (ab3480)

Product Name 

muscarinic Acetylcholine Receptor 1 antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to muscarinic Acetylcholine Receptor 1

Immunogen 

Fusion protein containing amino acids 269-320 from human m1 AChR.
This sequence is completely conserved in mouse, rat, and bovine protein.

Reacts with 

Ms

Predicted to react 
(species key)

Hu, Rat
(Due to sequence homology)

Specificity 

Detects recombinant mouse Muscarinic Acetylcholine Receptor 1 (m1AChR).

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
WB: Use at a concentration of 2 µg/ml.

Is unsuitable for IHC-P.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cell Membrane; multi-pass membrane protein

Research areas 

Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Acetylcholine
Neuroscience >> Neurotransmission >> Receptors / Channels >> GPCR >> Muscarinic Receptors

Relevance 

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract.
Muscarinic receptors are so called as they are more sensitive to the effects of the alkaloid muscarine, rather than nicotine.

Acetylcholine receptors (AChRs) mediate synaptic transmission at the neuromuscular junction. The channel-linked AChR that mediates rapid, excitatory actions of acetylcholine is called nicotinic AChR (nAChR) because it can be activated by nicotine. The non-channel linked AChR that medicates the slow actions of acetylcholine, which can be either inhibitory or excitatory, is called muscarinic AChR (mAChR) because it can be activated by muscarine.

The mAChRs are present in neurons of the central and peripheral nervous systems, cardiac and smooth muscle and various exocrine glands. There are 5 subtypes (m1-m5) of the receptor that have a tissue specific pattern of expression. The m1 receptor is localized primarily in brain tissue.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Immunogen affinity purified

Storage buffer 

PBS, 1 mg/ml BSA, 0.05% sodium azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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