Anti-Muscarinic Acetylcholine Receptor 2 antibody (ab41168)

Overview

  • Product name
    Anti-Muscarinic Acetylcholine Receptor 2 antibody
    See all Muscarinic Acetylcholine Receptor 2 primary antibodies
  • Description
    Rabbit polyclonal to Muscarinic Acetylcholine Receptor 2
  • Specificity
    M2 Muscarinic Receptor (457-466): 100% M2 Muscarinic Receptor: 50% No cross reactivity with M1, M3, M4 and M5 Muscarinic Receptors.
  • Tested applications
    Suitable for: WB, ICC/IF, ELISAmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide corresponding to C-terminal region (Rat) covalently attached onto a carrier protein.

  • Positive control
    • PLP fixed rat brain section; whole rat brain homogenate.

Properties

Applications

Our Abpromise guarantee covers the use of ab41168 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ICC/IF
ELISA
  • Application notes
    ELISA: Use at an assay dependent dilution.
    ICC/IF: 1/5000. Fix with PLP.
    WB: 1/1000. Predicted molecular weight: 52 kDa.

    With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
    • Involvement in disease
      Genetic variations in CHRM2 can influence susceptibility to major depressive disorder (MDD) [MIM:608516]. MDD is one of the most common psychiatric disorders. MDD is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
    • Sequence similarities
      Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
    • Cellular localization
      Cell membrane. Cell junction > synapse > postsynaptic cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • 7TM receptor antibody
      • Acetylcholine receptor, muscarinic, 2 antibody
      • AChR antibody
      • Acm2 antibody
      • ACM2_HUMAN antibody
      • Cholinergic receptor muscarinic 2 antibody
      • Cholinergic receptor, muscarinic 2, cardiac antibody
      • Cholinergic receptor, muscarinic 2, isoform a antibody
      • Cholinergic receptor, muscarinic 2a antibody
      • CHRM 2 antibody
      • CHRM2 antibody
      • chrm2a antibody
      • CM2 antibody
      • FLJ43243 antibody
      • HM 2 antibody
      • HM2 antibody
      • M2 antibody
      • M2 muscarinic receptor antibody
      • M2-mAChR antibody
      • MGC120006 antibody
      • MGC120007 antibody
      • Muscarinic acetylcholine receptor M2 antibody
      • Muscarinic M2 receptor antibody
      see all

    References

    ab41168 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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