Anti-Muscarinic Acetylcholine Receptor M3/CHRM3 antibody (ab60981)
Key features and details
- Rabbit polyclonal to Muscarinic Acetylcholine Receptor M3/CHRM3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Muscarinic Acetylcholine Receptor M3/CHRM3 antibody
See all Muscarinic Acetylcholine Receptor M3/CHRM3 primary antibodies -
Description
Rabbit polyclonal to Muscarinic Acetylcholine Receptor M3/CHRM3 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Sheep, Horse, Hamster, Cow, Pig, Chimpanzee, Monkey, Gorilla, Common marmoset, Orangutan, Elephant -
Immunogen
Synthetic peptide corresponding to Human Muscarinic Acetylcholine Receptor M3/CHRM3.
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Positive control
- Heart tissue
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.70
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab60981 was purified by peptide immunogen affinity column. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab60981 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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IHC-P
Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily. -
Cellular localization
Cell membrane. Cell junction > synapse > postsynaptic cell membrane. Basolateral cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 469725 Chimpanzee
- Entrez Gene: 281685 Cow
- Entrez Gene: 101154508 Gorilla
- Entrez Gene: 1131 Human
- Entrez Gene: 100144478 Pig
- Omim: 118494 Human
- SwissProt: Q9N2A4 Chimpanzee
- SwissProt: P41984 Cow
see all -
Alternative names
- AChR antibody
- ACM3_HUMAN antibody
- cholinergic receptor muscarinic 3 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab60981 has been referenced in 1 publication.
- Müller JJ et al. Fetal Sheep Mesenteric Resistance Arteries: Functional and Structural Maturation. J Vasc Res 54:259-271 (2017). PubMed: 28810262