• Product nameAnti-Muscleblind-like 1 antibody
    See all Muscleblind-like 1 primary antibodies
  • Description
    Goat polyclonal to Muscleblind-like 1
  • Specificityab80599 is expected to recognize the reported isoforms a - f (NP_066368.2, NP_997175.1, NP_997176.1, NP_997177.1, NP_997178.1 and NP_997179.1)
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Dog
  • Immunogen

    Synthetic peptide:


    , corresponding to C terminal amino acids 375 - 387 of Human Muscleblind-like 1

  • Positive control
    • HeLa cell lysate


  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab80599 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas


Our Abpromise guarantee covers the use of ab80599 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notesPeptide ELISA: antibody detection limit dilution 1/4000.
    WB: Use at a concentration of 1 - 3 µg/ml. Predicted molecular weight: 41 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionMediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues.
    • Tissue specificityHighly expressed in cardiac, skeletal muscle and during myoblast differentiation. Weakly expressed in other tissues (at protein level). Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
    • Involvement in diseasePlays a role in the pathogenesis of dystrophia myotonica type 1 (DM1) [MIM:160900]. A muscular disorder characterized by myotonia, muscle wasting in the distal extremities, cataract, hypogonadism, defective endocrine functions, male baldness and cardiac arrhythmias. Note=In muscle cells from DM1 patients, MBNL1 is sequestered by DMPK RNAs containing CUG triplet repeat expansions. MBNL1 binding is proportional to repeat length consistent with the direct correlation between the length of repeat expansion and disease severity.
    • Sequence similaritiesBelongs to the muscleblind family.
      Contains 4 C3H1-type zinc fingers.
    • Cellular localizationNucleus. Cytoplasm. Cytoplasmic granule. Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes. Colocalizes with nuclear foci of retained expanded-repeat transcripts in myotubes from patients affected by myotonic dystrophy.
    • Information by UniProt
    • Database links
    • Alternative names
      • EXP antibody
      • EXP35 antibody
      • EXP40 antibody
      • EXP42 antibody
      • KIAA0428 antibody
      • MBNL antibody
      • MBNL protein antibody
      • MBNL1 antibody
      • MBNL1_HUMAN antibody
      • Muscleblind 41kD isoform antibody
      • Muscleblind like antibody
      • Muscleblind like protein 1 antibody
      • Muscleblind like splicing regulator 1 antibody
      • Muscleblind-like protein 1 antibody
      • Triplet expansion RNA binding protein antibody
      • Triplet-expansion RNA-binding protein antibody
      see all

    Anti-Muscleblind-like 1 antibody images

    • Anti-Muscleblind-like 1 antibody (ab80599) at 1 µg/ml + HeLa cell lysate (in RIPA buffer) at 35 µg

      Predicted band size : 41 kDa
      Observed band size : 41 kDa

    References for Anti-Muscleblind-like 1 antibody (ab80599)

    ab80599 has not yet been referenced specifically in any publications.

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