• Product nameAnti-MVK antibody
    See all MVK primary antibodies
  • Description
    Mouse monoclonal to MVK
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: LIDMNQHHLN ALGVGHASLD QLCQVTRARG LHSKLTGAGG GGCGITLLKP GLEQPEVEAT KQALTSCGFD CLETSIGAPG VSIHSATSLD SRVQQALDGL , corresponding to amino acids 297-396 of human MVK (AAH16140) with a 26 kDa tag.

  • Positive control
    • MVK transfected 293T cell lysate



Our Abpromise guarantee covers the use of ab77463 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 42 kDa.
ELISA Use at an assay dependent dilution. Detection limit for this prodcut is ~3 ng/ml as a capture antibody.


  • FunctionMay be a regulatory site in cholesterol biosynthetic pathway.
  • PathwayIsoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
  • Involvement in diseaseDefects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
    Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
  • Sequence similaritiesBelongs to the GHMP kinase family. Mevalonate kinase subfamily.
  • Cellular localizationCytoplasm. Peroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ96772 antibody
    • KIME_HUMAN antibody
    • LH receptor mRNA binding protein antibody
    • LRBP antibody
    • Mevalonate kinase 1 antibody
    • Mevalonate kinase antibody
    • Mevalonic aciduria antibody
    • MK antibody
    • mvk antibody
    • MVLK antibody
    • POROK3 antibody
    see all

Anti-MVK antibody images

  • Anti-MVK antibody (ab77463) at 1/500 dilution + immunogen at 0.2 µg

    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

    Predicted band size : 42 kDa
    Observed band size : 34 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-MVK antibody (ab77463) at 1/500 dilution

    Lane 1 : MVK transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

    Predicted band size : 42 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 50 kDa. We are unsure as to the identity of these extra bands.
  • Detection limit for this product is ~3ng/ml as a capture antibody.

References for Anti-MVK antibody (ab77463)

ab77463 has not yet been referenced specifically in any publications.

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I am sorry to confirm that as far as we are aware, non of our MVK antibodies has been tested with samples from zebrafish. All tested and guaranteedspecies cross-reactivity in...

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