• Product name
  • Description
    Rabbit polyclonal to MVK
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Zebrafish
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 108-157 (AVLAFLYLYL SICRKQRALP SLDIVVWSEL PPGAGLGSSA AYSVCLAAAL) of Human MVK (NP_000422).

  • Positive control
    • Human fetal brain lysate



Our Abpromise guarantee covers the use of ab90888 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 42 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.


  • Function
    May be a regulatory site in cholesterol biosynthetic pathway.
  • Pathway
    Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.
  • Involvement in disease
    Defects in MVK are the cause of mevalonic aciduria (MEVA) [MIM:610377]. It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy, and ataxia.
    Defects in MVK are the cause of hyperimmunoglobulinemia D and periodic fever syndrome (HIDS) [MIM:260920]. HIDS is an autosomal recessive disease characterized by recurrent episodes of unexplained high fever associated with skin rash, diarrhea, adenopathy (swollen, tender lymph nodes), athralgias and/or arthritis. Concentration of IgD, and often IgA, are above normal.
  • Sequence similarities
    Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
  • Cellular localization
    Cytoplasm. Peroxisome.
  • Information by UniProt
  • Database links
  • Alternative names
    • FLJ96772 antibody
    • KIME_HUMAN antibody
    • LH receptor mRNA binding protein antibody
    • LRBP antibody
    • Mevalonate kinase 1 antibody
    • Mevalonate kinase antibody
    • Mevalonic aciduria antibody
    • MK antibody
    • mvk antibody
    • MVLK antibody
    • POROK3 antibody
    see all


  • Anti-MVK antibody (ab90888) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal brain lysate at 10 µg

    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 42 kDa


ab90888 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Thank you for your reply and I am pleased to hear you are interested in our testing discount offer for ab90888.

As previously discussed, as this antibody has not yet been tested in Zebrafish, I can offer a discount off a future purchase if y...

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Thank you very much for your continued interest in ab90888MVK antibody.

I am pleased to hear you would like to test this antibody in Zebrafish and can provide you with the details of how our testing discount programe works:

I can ...

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Thank you for contacting us and for your interest in our products.

I am sorry to confirm that as far as we are aware, non of our MVK antibodies has been tested with samples from zebrafish. All tested and guaranteedspecies cross-reactivity in...

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