Overview

  • Product nameAnti-MXI1 antibody
    See all MXI1 primary antibodies
  • Description
    Rabbit polyclonal to MXI1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog, Saccharomyces cerevisiae
  • Immunogen

    Synthetic peptide corresponding to a region within internal sequence amino acids 216-265 (GPQEMERIRM DSIGSTISSD RSDSEREEIE VDVESTEFSH GEVDNISTTS) of Human MXI1 (NP_569157).

  • Positive control
    • SH SYSY cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab90311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionTranscriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX.
  • Tissue specificityHigh levels found in the brain, heart and lung while lower levels are seen in the liver, kidney and skeletal muscle.
  • Involvement in diseaseDefects in MXI1 may be a cause of susceptibility to prostate cancer (PC) [MIM:176807]. It is a malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • bHLHc11 antibody
    • Class C basic helix-loop-helix protein 11 antibody
    • MAD 2 antibody
    • MAD2 antibody
    • MAX dimerization protein 2 antibody
    • MAX interacting protein 1 antibody
    • Max interactor 1 antibody
    • Max related transcription factor antibody
    • MAX-interacting protein 1 antibody
    • MGC43220 antibody
    • MXD 2 antibody
    • MXD2 antibody
    • MXI 1 antibody
    • MXI antibody
    • mxi1 antibody
    • MXI1 protein antibody
    • MXI1_HUMAN antibody
    • Protein MXI1 antibody
    see all

Anti-MXI1 antibody images

  • Anti-MXI1 antibody (ab90311) at 1 µg/ml (in 5% skim milk / PBS buffer) + SH SYSY cell lysate at 10 µg

    Secondary
    HRP conjugated anti-rabbit IgG at 1/50000 dilution

    Predicted band size : 33 kDa

References for Anti-MXI1 antibody (ab90311)

ab90311 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"