Recombinant
RabMAb

Anti-MYBPC3 antibody [EPR3008(2)] (ab108522)

Overview

  • Product name
    Anti-MYBPC3 antibody [EPR3008(2)]
    See all MYBPC3 primary antibodies
  • Description
    Rabbit monoclonal [EPR3008(2)] to MYBPC3
  • Tested applications
    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF or IHC-P
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human MYBPC3 aa 100-200. The exact sequence is proprietary.

  • Positive control
    • WB: Human heart tissue lysate.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated ‘PUR’ on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Stable for 12 months at -20°C.
  • Storage buffer
    pH: 7.20
    Preservative: 0.01% Sodium azide
    Constituents: 40% Glycerol, 0.05% BSA, 59% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    EPR3008(2)
  • Isotype
    IgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab108522 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 141 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
  • Target

    • Function
      Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
    • Involvement in disease
      Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
    • Sequence similarities
      Belongs to the immunoglobulin superfamily. MyBP family.
      Contains 3 fibronectin type-III domains.
      Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
    • Post-translational
      modifications
      Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
    • Information by UniProt
    • Database links
    • Alternative names
      • C protein cardiac muscle isoform antibody
      • C-protein antibody
      • cardiac muscle isoform antibody
      • Cardiac MyBP C antibody
      • Cardiac MyBP-C antibody
      • cardiac-type antibody
      • MYBPC3 antibody
      • myosin binding protein C cardiac antibody
      • Myosin binding protein C cardiac type antibody
      • Myosin-binding protein C antibody
      • MYPC3_HUMAN antibody
      see all

    Anti-MYBPC3 antibody [EPR3008(2)] images

    • Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/5000 dilution (purified) + Human heart tissue lysate at 10 µg

      Secondary
      Goat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/20000 dilution

      Predicted band size : 141 kDa
      Observed band size : 141 kDa

      Blocking and dilution buffer: 5% NFDM /TBST.

    • Anti-MYBPC3 antibody [EPR3008(2)] (ab108522) at 1/1000 dilution (unpurified) + Human heart tissue lysate at 10 µg

      Predicted band size : 141 kDa

    References for Anti-MYBPC3 antibody [EPR3008(2)] (ab108522)

    ab108522 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab108522.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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