Anti-MYBPC3 antibody - N-terminal (ab171153)

Overview

  • Product name
    Anti-MYBPC3 antibody - N-terminal
    See all MYBPC3 primary antibodies
  • Description
    Rabbit polyclonal to MYBPC3 - N-terminal
  • Tested applications
    Suitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human MYBPC3 aa 188-218 (N terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q14896

  • Positive control
    • Mouse heart tissue lysate; Human heart tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab171153 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 141 kDa.
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function
    Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role.
  • Involvement in disease
    Defects in MYBPC3 are the cause of cardiomyopathy familial hypertrophic type 4 (CMH4) [MIM:115197]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.
  • Sequence similarities
    Belongs to the immunoglobulin superfamily. MyBP family.
    Contains 3 fibronectin type-III domains.
    Contains 7 Ig-like C2-type (immunoglobulin-like) domains.
  • Post-translational
    modifications
    Substrate for phosphorylation by PKA and PKC. Reversible phosphorylation appears to modulate contraction.
  • Information by UniProt
  • Database links
  • Alternative names
    • C protein cardiac muscle isoform antibody
    • C-protein antibody
    • cardiac muscle isoform antibody
    • Cardiac MyBP C antibody
    • Cardiac MyBP-C antibody
    • Cardiac myosin binding protein C antibody
    • cardiac-type antibody
    • CMH4 antibody
    • FHC antibody
    • MYBP C antibody
    • MYBPC antibody
    • MYBPC3 antibody
    • Myosin binding protein C cardiac antibody
    • Myosin binding protein C cardiac-type antibody
    • Myosin-binding protein C antibody
    • myosin-binding protein C cardiac type antibody
    • MYPC3_HUMAN antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling MYBPC3 with ab171153 at 1/10 dilution, followed by peroxidase conjugation of the secondary antibody and DAB staining.

  • Anti-MYBPC3 antibody - N-terminal (ab171153) at 1/100 dilution + Mouse heart tissue lysate at 35 µg

    Predicted band size : 141 kDa

References

ab171153 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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