Anti-MYCBP2 antibody (ab86078)
Key features and details
- Rabbit polyclonal to MYCBP2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-MYCBP2 antibody
See all MYCBP2 primary antibodies -
Description
Rabbit polyclonal to MYCBP2 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Chicken, Guinea pig, Cow, Turkey, Pig, Chimpanzee, Rhesus monkey, Gorilla -
Immunogen
Synthetic peptide corresponding to Human MYCBP2 aa 2400-2500.
Database link: O75592 -
Positive control
- HeLa whole cell lysate (ab150035).
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 6.8
Preservative: 0.09% Sodium azide
Constituents: 0.1% BSA, Tris buffered saline -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab86078 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB | (1) |
1/2000 - 1/10000. Predicted molecular weight: 510 kDa.
|
Notes |
---|
WB
1/2000 - 1/10000. Predicted molecular weight: 510 kDa. |
Target
-
Relevance
MYCBP2 belongs to the highwire family. It is a probable E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. MYCBP2 may function as a facilitator or regulator of transcriptional activation by MYC and have a role during synaptogenesis. There are two different isoforms. -
Cellular localization
Nuclear -
Database links
- Entrez Gene: 23077 Human
- Entrez Gene: 105689 Mouse
- Entrez Gene: 290447 Rat
- Omim: 610392 Human
- SwissProt: O75592 Human
- SwissProt: Q7TPH6 Mouse
-
Alternative names
- AU023734 antibody
- AW107953 antibody
- AW546647 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (12)
ab86078 has been referenced in 12 publications.
- Romano D et al. Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma. Life Sci Alliance 5:N/A (2022). PubMed: 36038253
- Ma S et al. MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP in triple-negative breast cancer. Cell Mol Biol Lett 26:52 (2021). PubMed: 34895159
- Wang Y et al. NEDD4L-mediated LTF protein degradation limits ferroptosis. Biochem Biophys Res Commun 531:581-587 (2020). PubMed: 32811647
- Mabbitt PD et al. Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nat Chem Biol 16:1227-1236 (2020). PubMed: 32747811
- Qian J et al. lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR-495-3p/MYCBP axis. Int J Oncol 57:1157-1168 (2020). PubMed: 33300052