Anti-Mycobacterium tuberculosis RV2031 antibody [31C11] (ab64786)

Overview

  • Product nameAnti-Mycobacterium tuberculosis RV2031 antibody [31C11]
  • Description
    Mouse monoclonal [31C11] to Mycobacterium tuberculosis RV2031
  • SpecificityThis antibody recognises an amino acid sequence corresponding to the Rv2031 gene.
  • Tested applicationsSuitable for: Indirect ELISA, WBmore details
  • Species reactivity
    Reacts with Mycobacterium tuberculosis, RV2031 dormant protein from H37Rv strain.
  • Immunogen

    Recombinant full length protein: Rv2031.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: PBS, pH 7.4
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • Clone number31C11
  • MyelomaSp2/0
  • IsotypeIgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab64786 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Indirect ELISA Use at an assay dependent dilution.
WB Use at an assay dependent dilution.

Target

  • RelevanceMycobacterium tuberculosis is the most common cause of tuberculosis. Primary infection begins with inhalation of 1 to 10 aerosolised bacilli. The pathogenicity of the organism is determined by its ability to escape host immune responses as well as eliciting delayed hypersensitivity. Alveolar macrophages engulf the invading cells but are unable to mount an effective defense. Several virulence factors are responsible for this apparent failure; most notably in the mycobacterial cell wall are the cord factor, lipoarabinomannan, and the 65 kd heat shock protein or HSP65. The emergence of new strains of resistant Mycobacterium tuberculosis has created new interest in clinical diagnosis. Studies have shown immunohistochemical techniques to be superior to conventional special stains. Thus the demonstration of mycobacterial antigens are not only useful in establishing mycobacterial aetiology, but can also be used as an alternative method to the conventional Ziehl-Neelsen method.
  • Alternative names
    • RV2031 antibody

References for Anti-Mycobacterium tuberculosis RV2031 antibody [31C11] (ab64786)

This product has been referenced in:
  • Shi C  et al. Enhanced protection against tuberculosis by vaccination with recombinant BCG over-expressing HspX protein. Vaccine 28:5237-44 (2010). Read more (PubMed: 20538090) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"