FunctionMay regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation.
Tissue specificityDown-regulated in gastric cancer tissues.
Sequence similaritiesBelongs to the MYCT1 family.
Cellular localizationNucleus. Expressed in nuclei of hepatocellular carcinoma cell line Bel7402 cells.